Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application
Abstract Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although the current tumor treatment methods have therapeutic effect to a certain extent, they still have some shortcomings such as poor water solubility, short half-life, local and systemic toxicit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-024-02298-7 |
| _version_ | 1797273366179086336 |
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| author | Qian Yang Shisheng Li Haibo Ou Yuming Zhang Gangcai Zhu Shaohong Li Lanjie Lei |
| author_facet | Qian Yang Shisheng Li Haibo Ou Yuming Zhang Gangcai Zhu Shaohong Li Lanjie Lei |
| author_sort | Qian Yang |
| collection | DOAJ |
| description | Abstract Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although the current tumor treatment methods have therapeutic effect to a certain extent, they still have some shortcomings such as poor water solubility, short half-life, local and systemic toxicity. Therefore, how to deliver therapeutic agent so as to realize safe and effective anti-tumor therapy become a problem urgently to be solved in this field. As a medium of information exchange and material transport between cells, exosomes are considered to be a promising drug delivery carrier due to their nano-size, good biocompatibility, natural targeting, and easy modification. In this review, we summarize recent advances in the isolation, identification, drug loading, and modification of exosomes as drug carriers for tumor therapy alongside their application in tumor therapy. Basic knowledge of exosomes, such as their biogenesis, sources, and characterization methods, is also introduced herein. In addition, challenges related to the use of exosomes as drug delivery vehicles are discussed, along with future trends. This review provides a scientific basis for the application of exosome delivery systems in oncological therapy. Graphical Abstract |
| first_indexed | 2024-03-07T14:42:21Z |
| format | Article |
| id | doaj.art-0b7b7bf8f01840b2be635dabe2e75036 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-07T14:42:21Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-0b7b7bf8f01840b2be635dabe2e750362024-03-05T20:09:51ZengBMCJournal of Nanobiotechnology1477-31552024-01-0122114110.1186/s12951-024-02298-7Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical applicationQian Yang0Shisheng Li1Haibo Ou2Yuming Zhang3Gangcai Zhu4Shaohong Li5Lanjie Lei6Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South UniversityInstitute of Translational Medicine, Zhejiang Shuren UniversityAbstract Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although the current tumor treatment methods have therapeutic effect to a certain extent, they still have some shortcomings such as poor water solubility, short half-life, local and systemic toxicity. Therefore, how to deliver therapeutic agent so as to realize safe and effective anti-tumor therapy become a problem urgently to be solved in this field. As a medium of information exchange and material transport between cells, exosomes are considered to be a promising drug delivery carrier due to their nano-size, good biocompatibility, natural targeting, and easy modification. In this review, we summarize recent advances in the isolation, identification, drug loading, and modification of exosomes as drug carriers for tumor therapy alongside their application in tumor therapy. Basic knowledge of exosomes, such as their biogenesis, sources, and characterization methods, is also introduced herein. In addition, challenges related to the use of exosomes as drug delivery vehicles are discussed, along with future trends. This review provides a scientific basis for the application of exosome delivery systems in oncological therapy. Graphical Abstracthttps://doi.org/10.1186/s12951-024-02298-7ExosomeIsolationSurface functionalizationDrug deliveryTumor therapy |
| spellingShingle | Qian Yang Shisheng Li Haibo Ou Yuming Zhang Gangcai Zhu Shaohong Li Lanjie Lei Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application Journal of Nanobiotechnology Exosome Isolation Surface functionalization Drug delivery Tumor therapy |
| title | Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application |
| title_full | Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application |
| title_fullStr | Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application |
| title_full_unstemmed | Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application |
| title_short | Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application |
| title_sort | exosome based delivery strategies for tumor therapy an update on modification loading and clinical application |
| topic | Exosome Isolation Surface functionalization Drug delivery Tumor therapy |
| url | https://doi.org/10.1186/s12951-024-02298-7 |
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