Current and Future Pathways in <i>Aspergillus</i> Diagnosis
<i>Aspergillus fumigatus</i> has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/2/385 |
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| author | Radim Dobiáš David A. Stevens Vladimír Havlíček |
| author_facet | Radim Dobiáš David A. Stevens Vladimír Havlíček |
| author_sort | Radim Dobiáš |
| collection | DOAJ |
| description | <i>Aspergillus fumigatus</i> has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secretomes. This review summarizes the shortcomings of antibody tests compared to tests of fungal products in body fluids and highlights the application of β-<span style="font-variant: small-caps;">d</span>-glucan, galactomannan, and pentraxin 3 in bronchoalveolar lavage fluids. We also discuss the detection of nucleic acids and next-generation sequencing, along with newer studies on <i>Aspergillus</i> metallophores. |
| first_indexed | 2024-03-11T09:14:39Z |
| format | Article |
| id | doaj.art-0b829856c3dc4af08cf646aceae10b0d |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:14:39Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0b829856c3dc4af08cf646aceae10b0d2023-11-16T18:44:17ZengMDPI AGAntibiotics2079-63822023-02-0112238510.3390/antibiotics12020385Current and Future Pathways in <i>Aspergillus</i> DiagnosisRadim Dobiáš0David A. Stevens1Vladimír Havlíček2Department of Bacteriology and Mycology, Public Health Institute in Ostrava, Partyzánské Náměstí 2633/7, 702 00 Ostrava, Czech RepublicCalifornia Institute for Medical Research, 2260 Clove Drive, San Jose, CA 95128, USAInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic<i>Aspergillus fumigatus</i> has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secretomes. This review summarizes the shortcomings of antibody tests compared to tests of fungal products in body fluids and highlights the application of β-<span style="font-variant: small-caps;">d</span>-glucan, galactomannan, and pentraxin 3 in bronchoalveolar lavage fluids. We also discuss the detection of nucleic acids and next-generation sequencing, along with newer studies on <i>Aspergillus</i> metallophores.https://www.mdpi.com/2079-6382/12/2/385aspergillosisgalactomannanβ-<span style="font-variant: small-caps">d</span>-glucanPCRmetagenomic next-generation sequencinglateral flow |
| spellingShingle | Radim Dobiáš David A. Stevens Vladimír Havlíček Current and Future Pathways in <i>Aspergillus</i> Diagnosis Antibiotics aspergillosis galactomannan β-<span style="font-variant: small-caps">d</span>-glucan PCR metagenomic next-generation sequencing lateral flow |
| title | Current and Future Pathways in <i>Aspergillus</i> Diagnosis |
| title_full | Current and Future Pathways in <i>Aspergillus</i> Diagnosis |
| title_fullStr | Current and Future Pathways in <i>Aspergillus</i> Diagnosis |
| title_full_unstemmed | Current and Future Pathways in <i>Aspergillus</i> Diagnosis |
| title_short | Current and Future Pathways in <i>Aspergillus</i> Diagnosis |
| title_sort | current and future pathways in i aspergillus i diagnosis |
| topic | aspergillosis galactomannan β-<span style="font-variant: small-caps">d</span>-glucan PCR metagenomic next-generation sequencing lateral flow |
| url | https://www.mdpi.com/2079-6382/12/2/385 |
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