Heterogeneous Heat Absorption Is Complementary to Radiotherapy
(1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and sh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/4/901 |
| _version_ | 1797482051290529792 |
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| author | Andras Szasz |
| author_facet | Andras Szasz |
| author_sort | Andras Szasz |
| collection | DOAJ |
| description | (1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and show how it supports radiotherapy. (2) Methods: The targeted tissue’s natural electric and thermal heterogeneity is used for the selective heating of the cancer cells. The amplitude-modulated radiofrequency current focuses the energy absorption on the membrane rafts of the malignant cells. The energy partly “nonthermally” excites and partly heats the absorbing protein complexes. (3) Results: The excitation of the transmembrane proteins induces an extrinsic caspase-dependent apoptotic pathway, while the heat stress promotes the intrinsic caspase-dependent and independent apoptotic signals generated by mitochondria. The molecular changes synergize the method with radiotherapy and promote the abscopal effect. The mild average temperature (39–41 °C) intensifies the blood flow for promoting oxygenation in combination with radiotherapy. The preclinical experiences verify, and the clinical studies validate the method. (4) Conclusions: The heterogenic, molecular targeting has similarities with DNA strand-breaking in radiotherapy. The controlled energy absorption allows using a similar energy dose to radiotherapy (J/kg). The two therapies are synergistically combined. |
| first_indexed | 2024-03-09T22:23:46Z |
| format | Article |
| id | doaj.art-0b83312d8d6a456ea7abe679582998fa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:23:46Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0b83312d8d6a456ea7abe679582998fa2023-11-23T19:08:14ZengMDPI AGCancers2072-66942022-02-0114490110.3390/cancers14040901Heterogeneous Heat Absorption Is Complementary to RadiotherapyAndras Szasz0Biotechnics Department, Szent Istvan University, H-2040 Budaors, Hungary(1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and show how it supports radiotherapy. (2) Methods: The targeted tissue’s natural electric and thermal heterogeneity is used for the selective heating of the cancer cells. The amplitude-modulated radiofrequency current focuses the energy absorption on the membrane rafts of the malignant cells. The energy partly “nonthermally” excites and partly heats the absorbing protein complexes. (3) Results: The excitation of the transmembrane proteins induces an extrinsic caspase-dependent apoptotic pathway, while the heat stress promotes the intrinsic caspase-dependent and independent apoptotic signals generated by mitochondria. The molecular changes synergize the method with radiotherapy and promote the abscopal effect. The mild average temperature (39–41 °C) intensifies the blood flow for promoting oxygenation in combination with radiotherapy. The preclinical experiences verify, and the clinical studies validate the method. (4) Conclusions: The heterogenic, molecular targeting has similarities with DNA strand-breaking in radiotherapy. The controlled energy absorption allows using a similar energy dose to radiotherapy (J/kg). The two therapies are synergistically combined.https://www.mdpi.com/2072-6694/14/4/901loco-regional hyperthermiaoncologymodulated electro-hyperthermiacellular selectionbioelectromagneticscomplexity |
| spellingShingle | Andras Szasz Heterogeneous Heat Absorption Is Complementary to Radiotherapy Cancers loco-regional hyperthermia oncology modulated electro-hyperthermia cellular selection bioelectromagnetics complexity |
| title | Heterogeneous Heat Absorption Is Complementary to Radiotherapy |
| title_full | Heterogeneous Heat Absorption Is Complementary to Radiotherapy |
| title_fullStr | Heterogeneous Heat Absorption Is Complementary to Radiotherapy |
| title_full_unstemmed | Heterogeneous Heat Absorption Is Complementary to Radiotherapy |
| title_short | Heterogeneous Heat Absorption Is Complementary to Radiotherapy |
| title_sort | heterogeneous heat absorption is complementary to radiotherapy |
| topic | loco-regional hyperthermia oncology modulated electro-hyperthermia cellular selection bioelectromagnetics complexity |
| url | https://www.mdpi.com/2072-6694/14/4/901 |
| work_keys_str_mv | AT andrasszasz heterogeneousheatabsorptioniscomplementarytoradiotherapy |