Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis
The arterial vasa vasorum is a specialized microvasculature that provides critical perfusion required for the health of the arterial wall, and is increasingly recognized to play a central role in atherogenesis. Cardio-metabolic disease (CMD) (including hypertension, metabolic syndrome, obesity, diab...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/14/7574 |
| _version_ | 1797526903780802560 |
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| author | Jeanette Owusu Eugene Barrett |
| author_facet | Jeanette Owusu Eugene Barrett |
| author_sort | Jeanette Owusu |
| collection | DOAJ |
| description | The arterial vasa vasorum is a specialized microvasculature that provides critical perfusion required for the health of the arterial wall, and is increasingly recognized to play a central role in atherogenesis. Cardio-metabolic disease (CMD) (including hypertension, metabolic syndrome, obesity, diabetes, and pre-diabetes) is associated with insulin resistance, and characteristically injures the microvasculature in multiple tissues, (e.g., the eye, kidney, muscle, and heart). CMD also increases the risk for atherosclerotic vascular disease. Despite this, the impact of CMD on vasa vasorum structure and function has been little studied. Here we review emerging information on the early impact of CMD on the microvasculature in multiple tissues and consider the potential impact on atherosclerosis development and progression, if vasa vasorum is similarly affected. |
| first_indexed | 2024-03-10T09:36:56Z |
| format | Article |
| id | doaj.art-0b8394fd2b074e5ea573083c05257728 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:56Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0b8394fd2b074e5ea573083c052577282023-11-22T04:00:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214757410.3390/ijms22147574Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and AtherosclerosisJeanette Owusu0Eugene Barrett1Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USADepartment of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USAThe arterial vasa vasorum is a specialized microvasculature that provides critical perfusion required for the health of the arterial wall, and is increasingly recognized to play a central role in atherogenesis. Cardio-metabolic disease (CMD) (including hypertension, metabolic syndrome, obesity, diabetes, and pre-diabetes) is associated with insulin resistance, and characteristically injures the microvasculature in multiple tissues, (e.g., the eye, kidney, muscle, and heart). CMD also increases the risk for atherosclerotic vascular disease. Despite this, the impact of CMD on vasa vasorum structure and function has been little studied. Here we review emerging information on the early impact of CMD on the microvasculature in multiple tissues and consider the potential impact on atherosclerosis development and progression, if vasa vasorum is similarly affected.https://www.mdpi.com/1422-0067/22/14/7574atherosclerosisadventitial vasa vasorummicrovascular insulin resistanceangiogenesis |
| spellingShingle | Jeanette Owusu Eugene Barrett Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis International Journal of Molecular Sciences atherosclerosis adventitial vasa vasorum microvascular insulin resistance angiogenesis |
| title | Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis |
| title_full | Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis |
| title_fullStr | Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis |
| title_full_unstemmed | Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis |
| title_short | Early Microvascular Dysfunction: Is the Vasa Vasorum a “Missing Link” in Insulin Resistance and Atherosclerosis |
| title_sort | early microvascular dysfunction is the vasa vasorum a missing link in insulin resistance and atherosclerosis |
| topic | atherosclerosis adventitial vasa vasorum microvascular insulin resistance angiogenesis |
| url | https://www.mdpi.com/1422-0067/22/14/7574 |
| work_keys_str_mv | AT jeanetteowusu earlymicrovasculardysfunctionisthevasavasorumamissinglinkininsulinresistanceandatherosclerosis AT eugenebarrett earlymicrovasculardysfunctionisthevasavasorumamissinglinkininsulinresistanceandatherosclerosis |