Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co)
The Severe Acute Respiratory Syndrome (SARS) is a serious viral life-threatening and mortal respiratory illness caused by SARS-CoV. SARS-CoV plays an essential role in the viral replication cycle. It is considered a potential target for SARS inhibitor development. A series of twenty eight bioactive...
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| Format: | Article |
| Language: | English |
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Salahaddin University-Erbil
2019-04-01
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| Series: | Zanco Journal of Pure and Applied Sciences |
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| Online Access: | https://zancojournals.su.edu.krd/index.php/JPAS/article/view/2575 |
| _version_ | 1828218897382244352 |
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| author | Hassan Abdallah |
| author_facet | Hassan Abdallah |
| author_sort | Hassan Abdallah |
| collection | DOAJ |
| description | The Severe Acute Respiratory Syndrome (SARS) is a serious viral life-threatening and mortal respiratory illness caused by SARS-CoV. SARS-CoV plays an essential role in the viral replication cycle. It is considered a potential target for SARS inhibitor development. A series of twenty eight bioactive imidazole compounds as possible SARS-CoV inhibitors were designed and evaluated using computational calculations. Possible binding interaction modes were proposed by molecular docking studies. Among all studied compounds, compounds 5, 15 and 22 showed most potent inhibitory activity against SARS-CoV. These results indicated that these inhibitors could be potentially developed into anti-SARS drugs. |
| first_indexed | 2024-04-12T16:09:34Z |
| format | Article |
| id | doaj.art-0b83b363a2c440a0a20bae16220544e8 |
| institution | Directory Open Access Journal |
| issn | 2218-0230 2412-3986 |
| language | English |
| last_indexed | 2024-04-12T16:09:34Z |
| publishDate | 2019-04-01 |
| publisher | Salahaddin University-Erbil |
| record_format | Article |
| series | Zanco Journal of Pure and Applied Sciences |
| spelling | doaj.art-0b83b363a2c440a0a20bae16220544e82022-12-22T03:25:56ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862019-04-01312717810.21271/ZJPAS.31.2.10Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co)Hassan Abdallah0Chemistry Department, College of Education, Salahaddin UniversityThe Severe Acute Respiratory Syndrome (SARS) is a serious viral life-threatening and mortal respiratory illness caused by SARS-CoV. SARS-CoV plays an essential role in the viral replication cycle. It is considered a potential target for SARS inhibitor development. A series of twenty eight bioactive imidazole compounds as possible SARS-CoV inhibitors were designed and evaluated using computational calculations. Possible binding interaction modes were proposed by molecular docking studies. Among all studied compounds, compounds 5, 15 and 22 showed most potent inhibitory activity against SARS-CoV. These results indicated that these inhibitors could be potentially developed into anti-SARS drugs.https://zancojournals.su.edu.krd/index.php/JPAS/article/view/2575imidazoleCoronadocking studies |
| spellingShingle | Hassan Abdallah Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co) Zanco Journal of Pure and Applied Sciences imidazole Corona docking studies |
| title | Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co) |
| title_full | Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co) |
| title_fullStr | Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co) |
| title_full_unstemmed | Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co) |
| title_short | Theoretical study for the inhibition ability of some bioactive imidazole derivatives against the Middle-East respiratory syndrome corona virus (MERS-Co) |
| title_sort | theoretical study for the inhibition ability of some bioactive imidazole derivatives against the middle east respiratory syndrome corona virus mers co |
| topic | imidazole Corona docking studies |
| url | https://zancojournals.su.edu.krd/index.php/JPAS/article/view/2575 |
| work_keys_str_mv | AT hassanabdallah theoreticalstudyfortheinhibitionabilityofsomebioactiveimidazolederivativesagainstthemiddleeastrespiratorysyndromecoronavirusmersco |