The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial
Abstract Background Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive remediation therapy (CRT) aims to improve cognition in neuropsychiatric d...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-018-2553-3 |
| _version_ | 1819030651210301440 |
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| author | Til Wykes Eileen Joyce Tjasa Velikonja Andrew Watson Gregory Aarons Max Birchwood Matteo Cella Sue Dopson David Fowler Kathy Greenwood Sonia Johnson Paul McCrone Jesus Perez Andrew Pickles Clare Reeder Diana Rose Swaran Singh Dominic Stringer Matthew Taylor Rumina Taylor Rachel Upthegrove |
| author_facet | Til Wykes Eileen Joyce Tjasa Velikonja Andrew Watson Gregory Aarons Max Birchwood Matteo Cella Sue Dopson David Fowler Kathy Greenwood Sonia Johnson Paul McCrone Jesus Perez Andrew Pickles Clare Reeder Diana Rose Swaran Singh Dominic Stringer Matthew Taylor Rumina Taylor Rachel Upthegrove |
| author_sort | Til Wykes |
| collection | DOAJ |
| description | Abstract Background Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive remediation therapy (CRT) aims to improve cognition in neuropsychiatric disorders, with the ultimate goal of improving functional recovery. Studies suggest that intervening early in the course of the disorder will have the most benefit, so this study will be based in early intervention services, which treat individuals in the first few years following the onset of the disorder. The overall aim is to investigate different methods of CRT. Methods This is a multicentre, randomised, single-blinded, controlled trial based in early intervention services in National Health Service Mental Health Trusts in six English research sites. Three different methods of providing CRT (intensive, group, and independent) will be compared with treatment as usual. We will recruit 720 service users aged between 16 and 45 over 3 years who have a research diagnosis of non-affective psychosis and will be at least 3 months from the onset of the first episode of psychosis. The primary outcome measure will be the degree to which participants have achieved their stated goals using the Goal Attainment Scale. Secondary outcome measures will include improvements in cognitive function, social function, self-esteem, and clinical symptoms. Discussion It has already been established that cognitive remediation improves cognitive function in people with schizophrenia. Successful implementation in mental health services has the potential to change the recovery trajectory of individuals with schizophrenia-spectrum disorders. However, the best mode of implementation, in terms of efficacy, service user and team preference, and cost-effectiveness is still unclear. The CIRCuiTS trial will provide guidance for a large-scale roll-out of CRT to mental health services where cognitive difficulties impact recovery and resilience. Trial registration ISRCTN, ISRCTN14678860, Registered on 6 June 2016. |
| first_indexed | 2024-12-21T06:33:32Z |
| format | Article |
| id | doaj.art-0b83b3e196504d27bcd663c6f342d887 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-21T06:33:32Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-0b83b3e196504d27bcd663c6f342d8872022-12-21T19:12:56ZengBMCTrials1745-62152018-03-0119111210.1186/s13063-018-2553-3The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trialTil Wykes0Eileen Joyce1Tjasa Velikonja2Andrew Watson3Gregory Aarons4Max Birchwood5Matteo Cella6Sue Dopson7David Fowler8Kathy Greenwood9Sonia Johnson10Paul McCrone11Jesus Perez12Andrew Pickles13Clare Reeder14Diana Rose15Swaran Singh16Dominic Stringer17Matthew Taylor18Rumina Taylor19Rachel Upthegrove20Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonUCL Institute of NeurologyDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonUCL Institute of NeurologyUniversity of California, San DiegoMental Health and Wellbeing, Warwick Medical School, University of WarwickDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSaïd Business School, University of OxfordPsychology Department, University of SussexSussex Partnership NHS Foundation Trust and University of SussexDivision of Psychiatry, UCL, Mental Health Sciences UnitKing’s Health Economics, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonCambridge & Peterborough NHS Foundation Trust, CAMEODepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonHealth Services and Population Research Department, Institute of Psychology, Psychiatry and Neuroscience, King’s College LondonWarwick Medical School, University of WarwickDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSouth London & Maudsley NHS Foundation Trust, Maudsley HospitalDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonCollege of Medical and Dental Sciences, University of BirminghamAbstract Background Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive remediation therapy (CRT) aims to improve cognition in neuropsychiatric disorders, with the ultimate goal of improving functional recovery. Studies suggest that intervening early in the course of the disorder will have the most benefit, so this study will be based in early intervention services, which treat individuals in the first few years following the onset of the disorder. The overall aim is to investigate different methods of CRT. Methods This is a multicentre, randomised, single-blinded, controlled trial based in early intervention services in National Health Service Mental Health Trusts in six English research sites. Three different methods of providing CRT (intensive, group, and independent) will be compared with treatment as usual. We will recruit 720 service users aged between 16 and 45 over 3 years who have a research diagnosis of non-affective psychosis and will be at least 3 months from the onset of the first episode of psychosis. The primary outcome measure will be the degree to which participants have achieved their stated goals using the Goal Attainment Scale. Secondary outcome measures will include improvements in cognitive function, social function, self-esteem, and clinical symptoms. Discussion It has already been established that cognitive remediation improves cognitive function in people with schizophrenia. Successful implementation in mental health services has the potential to change the recovery trajectory of individuals with schizophrenia-spectrum disorders. However, the best mode of implementation, in terms of efficacy, service user and team preference, and cost-effectiveness is still unclear. The CIRCuiTS trial will provide guidance for a large-scale roll-out of CRT to mental health services where cognitive difficulties impact recovery and resilience. Trial registration ISRCTN, ISRCTN14678860, Registered on 6 June 2016.http://link.springer.com/article/10.1186/s13063-018-2553-3CognitionCognitive enhancementCognitive remediationCognitive trainingEarly psychosisImplementation |
| spellingShingle | Til Wykes Eileen Joyce Tjasa Velikonja Andrew Watson Gregory Aarons Max Birchwood Matteo Cella Sue Dopson David Fowler Kathy Greenwood Sonia Johnson Paul McCrone Jesus Perez Andrew Pickles Clare Reeder Diana Rose Swaran Singh Dominic Stringer Matthew Taylor Rumina Taylor Rachel Upthegrove The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial Trials Cognition Cognitive enhancement Cognitive remediation Cognitive training Early psychosis Implementation |
| title | The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial |
| title_full | The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial |
| title_fullStr | The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial |
| title_full_unstemmed | The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial |
| title_short | The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial |
| title_sort | circuits study implementation of cognitive remediation in early intervention services protocol for a randomised controlled trial |
| topic | Cognition Cognitive enhancement Cognitive remediation Cognitive training Early psychosis Implementation |
| url | http://link.springer.com/article/10.1186/s13063-018-2553-3 |
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