Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats
Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7650/17900_CE(RA1)_F(T)_PF1(RoAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: The medicinal value of Morinda citrifolia L. (commonly
known as Noni) has been explored in ancient folk remedies with a
wide range of therapeutic utility, including antibacterial, antiviral,
antifungal, antitumour, analgesic, hypotensive, anti-inflammatory
and immune enhancing effects.
Aim: The present study was designed to evaluate the effects
of Noni fruit juice on serum lipid profile in high fat diet induced
murine model of dyslipidemia.
Materials and Methods: Hyperlipidemia was induced by
feeding a cholesterol rich high fat diet for 45 days in wistar
albino rats of either sex (n=8). Noni fruit juice administered
at 50mg/kg/day and 100mg/kg/day, per oral, was compared
with the standard drug Atorvastatin (10mg/kg/day, oral) fed
for the latter 30 days. The blood samples were then sent for
complete blood lipid profile, after 30 days of treatment. The data
presented as mean ± SEM was analyzed using one-way ANOVA
followed by Tukey’s post-hoc test. The p <0.05 was considered
as statistically significant.
Results: The Noni fruit juice treated group showed a significant
decrease in the total cholesterol, triglycerides and very low
density lipoprotein - Cholesterol at both the doses when
compared to the disease control (p<0.05). However, the
decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47
mg/dL) levels observed with the noni fruit juice at the 50mg/kg
dose employed, failed to show a statistical significance when
compared to atorvastatin.
Conclusion: The present study provides evidence for the
hypolipidemic activity of Noni fruit juice in high fat diet induced
hyperlipidemia in rats. |
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| ISSN: | 2249-782X 0973-709X |