Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats
Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effe...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7650/17900_CE(RA1)_F(T)_PF1(RoAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818256303613542400 |
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| author | Ahsan Shoeb M.C. Alwar Preethi J. Shenoy P. Gokul |
| author_facet | Ahsan Shoeb M.C. Alwar Preethi J. Shenoy P. Gokul |
| author_sort | Ahsan Shoeb |
| collection | DOAJ |
| description | Introduction: The medicinal value of Morinda citrifolia L. (commonly
known as Noni) has been explored in ancient folk remedies with a
wide range of therapeutic utility, including antibacterial, antiviral,
antifungal, antitumour, analgesic, hypotensive, anti-inflammatory
and immune enhancing effects.
Aim: The present study was designed to evaluate the effects
of Noni fruit juice on serum lipid profile in high fat diet induced
murine model of dyslipidemia.
Materials and Methods: Hyperlipidemia was induced by
feeding a cholesterol rich high fat diet for 45 days in wistar
albino rats of either sex (n=8). Noni fruit juice administered
at 50mg/kg/day and 100mg/kg/day, per oral, was compared
with the standard drug Atorvastatin (10mg/kg/day, oral) fed
for the latter 30 days. The blood samples were then sent for
complete blood lipid profile, after 30 days of treatment. The data
presented as mean ± SEM was analyzed using one-way ANOVA
followed by Tukey’s post-hoc test. The p <0.05 was considered
as statistically significant.
Results: The Noni fruit juice treated group showed a significant
decrease in the total cholesterol, triglycerides and very low
density lipoprotein - Cholesterol at both the doses when
compared to the disease control (p<0.05). However, the
decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47
mg/dL) levels observed with the noni fruit juice at the 50mg/kg
dose employed, failed to show a statistical significance when
compared to atorvastatin.
Conclusion: The present study provides evidence for the
hypolipidemic activity of Noni fruit juice in high fat diet induced
hyperlipidemia in rats. |
| first_indexed | 2024-12-12T17:25:37Z |
| format | Article |
| id | doaj.art-0b83df8fd5dd45a48f09a21b51e0ca63 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T17:25:37Z |
| publishDate | 2016-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0b83df8fd5dd45a48f09a21b51e0ca632022-12-22T00:17:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-04-01104FF06FF1010.7860/JCDR/2016/17900.7650Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in RatsAhsan Shoeb0M.C. Alwar1Preethi J. Shenoy2P. Gokul3Post Graduate Student, Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University, Mangalore, Karnataka, India.Professor, Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University, Mangalore, Karnataka, India.Associate Professor, Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University, Mangalore, Karnataka, India.Post Graduate Student, Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal University, Mangalore, Karnataka, India.Introduction: The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects. Aim: The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia. Materials and Methods: Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The p <0.05 was considered as statistically significant. Results: The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (p<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin. Conclusion: The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.https://jcdr.net/articles/PDF/7650/17900_CE(RA1)_F(T)_PF1(RoAK)_PFA(AK)_PF2(PAG).pdfhypolipidemic activityhigh density lipoproteinlow density lipoproteinnoni fruitplasma lipidstotal cholesterolvery low density lipoprotein |
| spellingShingle | Ahsan Shoeb M.C. Alwar Preethi J. Shenoy P. Gokul Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats Journal of Clinical and Diagnostic Research hypolipidemic activity high density lipoprotein low density lipoprotein noni fruit plasma lipids total cholesterol very low density lipoprotein |
| title | Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats |
| title_full | Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats |
| title_fullStr | Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats |
| title_full_unstemmed | Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats |
| title_short | Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats |
| title_sort | effect of morinda citrifolia noni fruit juice on high fat diet induced dyslipidemia in rats |
| topic | hypolipidemic activity high density lipoprotein low density lipoprotein noni fruit plasma lipids total cholesterol very low density lipoprotein |
| url | https://jcdr.net/articles/PDF/7650/17900_CE(RA1)_F(T)_PF1(RoAK)_PFA(AK)_PF2(PAG).pdf |
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