Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity.
Obesity is the principal symptom of metabolic syndrome, which refers to a group of risk factors that increase the likelihood of atherosclerosis. In recent decades there has been a sharp rise in the incidence of obesity throughout the developed world. Iso-α-acids, the bitter compounds derived from ho...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4476742?pdf=render |
| _version_ | 1818657861054496768 |
|---|---|
| author | Yumie Morimoto-Kobayashi Kazuaki Ohara Chika Takahashi Sayoko Kitao Guanying Wang Yoshimasa Taniguchi Mikio Katayama Katsuya Nagai |
| author_facet | Yumie Morimoto-Kobayashi Kazuaki Ohara Chika Takahashi Sayoko Kitao Guanying Wang Yoshimasa Taniguchi Mikio Katayama Katsuya Nagai |
| author_sort | Yumie Morimoto-Kobayashi |
| collection | DOAJ |
| description | Obesity is the principal symptom of metabolic syndrome, which refers to a group of risk factors that increase the likelihood of atherosclerosis. In recent decades there has been a sharp rise in the incidence of obesity throughout the developed world. Iso-α-acids, the bitter compounds derived from hops in beer, have been shown to prevent diet-induced obesity by increasing lipid oxidation in the liver and inhibition of lipid absorption from the intestine. Whereas the sharp bitterness induced by effective dose of iso-α-acids precludes their acceptance as a nutrient, matured hop bittering components (MHB) appear to be more agreeable. Therefore, we tested MHB for an effect on ameliorating diet-induced body fat accumulation in rodents. MHB ingestion had a beneficial effect but, compared to iso-α-acids and despite containing structurally similar compounds, acted via different mechanisms to reduce body fat accumulation. MHB supplementation significantly reduced body weight gain, epididymal white adipose tissue weight, and plasma non-esterified free fatty acid levels in diet-induced obese mice. We also found that uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) was significantly increased in MHB-fed mice at both the mRNA and protein levels. In addition, MHB administration in rats induced the β-adrenergic signaling cascade, which is related to cAMP accumulation in BAT, suggesting that MHB could modulate sympathetic nerve activity innervating BAT (BAT-SNA). Indeed, single oral administration of MHB elevated BAT-SNA in rats, and this elevation was dissipated by subdiaphragmatic vagotomy. Single oral administration of MHB maintained BAT temperature at a significantly higher level than in control rats. Taken together, these findings indicate that MHB ameliorates diet-induced body fat accumulation, at least partly, by enhancing thermogenesis in BAT via BAT-SNA activation. Our data suggests that MHB is a useful tool for developing functional foods or beverages to counteract the accumulation of body fat. |
| first_indexed | 2024-12-17T03:48:12Z |
| format | Article |
| id | doaj.art-0b840cd404384ece8e57d29e9ae13217 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T03:48:12Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0b840cd404384ece8e57d29e9ae132172022-12-21T22:04:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013104210.1371/journal.pone.0131042Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity.Yumie Morimoto-KobayashiKazuaki OharaChika TakahashiSayoko KitaoGuanying WangYoshimasa TaniguchiMikio KatayamaKatsuya NagaiObesity is the principal symptom of metabolic syndrome, which refers to a group of risk factors that increase the likelihood of atherosclerosis. In recent decades there has been a sharp rise in the incidence of obesity throughout the developed world. Iso-α-acids, the bitter compounds derived from hops in beer, have been shown to prevent diet-induced obesity by increasing lipid oxidation in the liver and inhibition of lipid absorption from the intestine. Whereas the sharp bitterness induced by effective dose of iso-α-acids precludes their acceptance as a nutrient, matured hop bittering components (MHB) appear to be more agreeable. Therefore, we tested MHB for an effect on ameliorating diet-induced body fat accumulation in rodents. MHB ingestion had a beneficial effect but, compared to iso-α-acids and despite containing structurally similar compounds, acted via different mechanisms to reduce body fat accumulation. MHB supplementation significantly reduced body weight gain, epididymal white adipose tissue weight, and plasma non-esterified free fatty acid levels in diet-induced obese mice. We also found that uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) was significantly increased in MHB-fed mice at both the mRNA and protein levels. In addition, MHB administration in rats induced the β-adrenergic signaling cascade, which is related to cAMP accumulation in BAT, suggesting that MHB could modulate sympathetic nerve activity innervating BAT (BAT-SNA). Indeed, single oral administration of MHB elevated BAT-SNA in rats, and this elevation was dissipated by subdiaphragmatic vagotomy. Single oral administration of MHB maintained BAT temperature at a significantly higher level than in control rats. Taken together, these findings indicate that MHB ameliorates diet-induced body fat accumulation, at least partly, by enhancing thermogenesis in BAT via BAT-SNA activation. Our data suggests that MHB is a useful tool for developing functional foods or beverages to counteract the accumulation of body fat.http://europepmc.org/articles/PMC4476742?pdf=render |
| spellingShingle | Yumie Morimoto-Kobayashi Kazuaki Ohara Chika Takahashi Sayoko Kitao Guanying Wang Yoshimasa Taniguchi Mikio Katayama Katsuya Nagai Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. PLoS ONE |
| title | Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. |
| title_full | Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. |
| title_fullStr | Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. |
| title_full_unstemmed | Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. |
| title_short | Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. |
| title_sort | matured hop bittering components induce thermogenesis in brown adipose tissue via sympathetic nerve activity |
| url | http://europepmc.org/articles/PMC4476742?pdf=render |
| work_keys_str_mv | AT yumiemorimotokobayashi maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT kazuakiohara maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT chikatakahashi maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT sayokokitao maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT guanyingwang maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT yoshimasataniguchi maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT mikiokatayama maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity AT katsuyanagai maturedhopbitteringcomponentsinducethermogenesisinbrownadiposetissueviasympatheticnerveactivity |