Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target
Lipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/11/1057 |
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| author | Roberta Modica Anna La Salvia Alessia Liccardi Giuseppe Cannavale Roberto Minotta Elio Benevento Antongiulio Faggiano Annamaria Colao |
| author_facet | Roberta Modica Anna La Salvia Alessia Liccardi Giuseppe Cannavale Roberto Minotta Elio Benevento Antongiulio Faggiano Annamaria Colao |
| author_sort | Roberta Modica |
| collection | DOAJ |
| description | Lipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment and may have a role in treatment resistance. Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies with increasing incidence, whose mechanisms of cancer initiation and progression are far from being fully understood. Alterations of lipid metabolism may be common across various cancer types, but data about NENs are scattered and heterogeneous. Herein, we provide an overview of the relevant literature on lipid metabolism and alterations in NENs. The available evidence both in basic and clinical research about lipid metabolism in NENs, including therapeutic effects on lipid homeostasis, are summarized. Additionally, the potential of targeting the lipid profile in NEN therapy is also discussed, and areas for further research are proposed. |
| first_indexed | 2024-03-09T18:50:32Z |
| format | Article |
| id | doaj.art-0b84c308d21c4fa39ab39376ba534901 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T18:50:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-0b84c308d21c4fa39ab39376ba5349012023-11-24T05:50:20ZengMDPI AGMetabolites2218-19892022-11-011211105710.3390/metabo12111057Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic TargetRoberta Modica0Anna La Salvia1Alessia Liccardi2Giuseppe Cannavale3Roberto Minotta4Elio Benevento5Antongiulio Faggiano6Annamaria Colao7Department of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, ItalyDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, ItalyEndocrinology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, ENETS Center of Excellence, Sapienza University of Rome, 00189 Rome, ItalyDepartment of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, ItalyLipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment and may have a role in treatment resistance. Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies with increasing incidence, whose mechanisms of cancer initiation and progression are far from being fully understood. Alterations of lipid metabolism may be common across various cancer types, but data about NENs are scattered and heterogeneous. Herein, we provide an overview of the relevant literature on lipid metabolism and alterations in NENs. The available evidence both in basic and clinical research about lipid metabolism in NENs, including therapeutic effects on lipid homeostasis, are summarized. Additionally, the potential of targeting the lipid profile in NEN therapy is also discussed, and areas for further research are proposed.https://www.mdpi.com/2218-1989/12/11/1057lipid metabolismcholesterolmetabolic syndromeneuroendocrine neoplasmneuroendocrine tumorcancer |
| spellingShingle | Roberta Modica Anna La Salvia Alessia Liccardi Giuseppe Cannavale Roberto Minotta Elio Benevento Antongiulio Faggiano Annamaria Colao Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target Metabolites lipid metabolism cholesterol metabolic syndrome neuroendocrine neoplasm neuroendocrine tumor cancer |
| title | Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target |
| title_full | Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target |
| title_fullStr | Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target |
| title_full_unstemmed | Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target |
| title_short | Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target |
| title_sort | lipid metabolism and homeostasis in patients with neuroendocrine neoplasms from risk factor to potential therapeutic target |
| topic | lipid metabolism cholesterol metabolic syndrome neuroendocrine neoplasm neuroendocrine tumor cancer |
| url | https://www.mdpi.com/2218-1989/12/11/1057 |
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