Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review
Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating cond...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-12-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354211065038 |
| _version_ | 1819006293675868160 |
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| author | Soo Liang Ooi PhD candidate Ron Campbell BMedSc(Hons), FRACGP Sok Cheon Pak PhD Terry Golombick PhD Arumugam Manoharan MD, FRACP, FRCPA Raj Ramakrishna MD, FRACP, FRCPA Vladimir Badmaev MD, PhD Janet Schloss PhD |
| author_facet | Soo Liang Ooi PhD candidate Ron Campbell BMedSc(Hons), FRACGP Sok Cheon Pak PhD Terry Golombick PhD Arumugam Manoharan MD, FRACP, FRCPA Raj Ramakrishna MD, FRACP, FRCPA Vladimir Badmaev MD, PhD Janet Schloss PhD |
| author_sort | Soo Liang Ooi PhD candidate |
| collection | DOAJ |
| description | Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol. |
| first_indexed | 2024-12-21T00:06:23Z |
| format | Article |
| id | doaj.art-0b8550ac2c864e7c8a06dc0b95339bc8 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-21T00:06:23Z |
| publishDate | 2021-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-0b8550ac2c864e7c8a06dc0b95339bc82022-12-21T19:22:28ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2021-12-012010.1177/15347354211065038Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative ReviewSoo Liang Ooi PhD candidate0Ron Campbell BMedSc(Hons), FRACGP1Sok Cheon Pak PhD2Terry Golombick PhD3Arumugam Manoharan MD, FRACP, FRCPA4Raj Ramakrishna MD, FRACP, FRCPA5Vladimir Badmaev MD, PhD6Janet Schloss PhD7Charles Sturt University, Bathurst, NSW, AustraliaThe Oaks Medical Practice, The Oaks, NSW, AustraliaCharles Sturt University, Bathurst, NSW, AustraliaSt George Hospital, Kogarah, NSW, AustraliaUniversity of Wollongong Australia, Wollongong NSW, AustraliaUniversity of Wollongong Australia, Wollongong NSW, AustraliaAmerican Medical Holdings, Inc., Staten Island, NY, USASouthern Cross University, Lismore, NSW, AustraliaMyelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol.https://doi.org/10.1177/15347354211065038 |
| spellingShingle | Soo Liang Ooi PhD candidate Ron Campbell BMedSc(Hons), FRACGP Sok Cheon Pak PhD Terry Golombick PhD Arumugam Manoharan MD, FRACP, FRCPA Raj Ramakrishna MD, FRACP, FRCPA Vladimir Badmaev MD, PhD Janet Schloss PhD Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review Integrative Cancer Therapies |
| title | Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review |
| title_full | Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review |
| title_fullStr | Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review |
| title_full_unstemmed | Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review |
| title_short | Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review |
| title_sort | is 6 shogaol an effective phytochemical for patients with lower risk myelodysplastic syndrome a narrative review |
| url | https://doi.org/10.1177/15347354211065038 |
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