The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome
Objectives: We sought to evaluate the effects of omega-3 and vitamin E co-supplementation on carotid intima-media thickness (CIMT) and inflammatory factors in patients with polycystic ovary syndrome (PCOS). Methods: This randomized, double-blind, placebo-controlled trial was done among 60 women with...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2018-11-01
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| Series: | Oman Medical Journal |
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| Online Access: | http://omjournal.org/articleDetails.aspx?coType=1&aId=2398 |
| _version_ | 1818676124393144320 |
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| author | Hamid Reza Talari Somayyeh Poladchang Yaser Hamidian Mansooreh Samimi Hamid Reza Gilasi Faraneh Afshar Ebrahimi Zatollah Asemi |
| author_facet | Hamid Reza Talari Somayyeh Poladchang Yaser Hamidian Mansooreh Samimi Hamid Reza Gilasi Faraneh Afshar Ebrahimi Zatollah Asemi |
| author_sort | Hamid Reza Talari |
| collection | DOAJ |
| description | Objectives: We sought to evaluate the effects of omega-3 and vitamin E co-supplementation on carotid intima-media thickness (CIMT) and inflammatory factors in patients with polycystic ovary syndrome (PCOS). Methods: This randomized, double-blind, placebo-controlled trial was done among 60 women with PCOS. Participants were randomly assigned into two groups (n = 30 each group) and assigned to take either 1000 mg omega-3 plus 400 IU vitamin E supplements or a placebo for 12 weeks. Results: Compared with placebo, omega-3 and vitamin E co-supplementation led to significant decreases in maximum levels of left CIMT (-0.006±0.006 vs. +0.002±0.007 mm, p < 0.001), mean levels of left CIMT (-0.005±0.006 vs. +0.002±0.010 mm, p = 0.010), maximum levels of right CIMT (-0.006±0.010 vs. +0.006±0.010 mm, p = 0.010), and mean levels of right CIMT (-0.005±0.005 vs. +0.001±0.010 mm, p = 0.020). Change in high-sensitivity C-reactive protein (hs-CRP) (-390.6±942.9 vs. +237.0±754.3 ng/mL, p = 0.006) was significantly different between the supplemented patients and placebo group. We did not observe any significant effect in plasma nitric oxide (NO) values following supplementation with omega-3 plus vitamin E compared with the placebo. Conclusions: Co-supplementation with omega-3 and vitamin E for 12 weeks among patients with PCOS had beneficial effects on CIMT and serum hs-CRP values, but unchanged NO values. |
| first_indexed | 2024-12-17T08:38:29Z |
| format | Article |
| id | doaj.art-0b858a28ccb34b69bb2fad3f7956d925 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-17T08:38:29Z |
| publishDate | 2018-11-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-0b858a28ccb34b69bb2fad3f7956d9252022-12-21T21:56:24ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042018-11-0133647348010.5001/omj.2018.88The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary SyndromeHamid Reza Talari0Somayyeh Poladchang1Yaser Hamidian2Mansooreh Samimi3Hamid Reza Gilasi4Faraneh Afshar Ebrahimi5Zatollah Asemi6Department of Radiology, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Kashan University of Medical Sciences, Kashan, IranDepartment of Gynecology and Obstetrics, Kashan University of Medical Sciences, Kashan, IranDepartment of Epidemiology and Biostatistics, Kashan University of Medical Sciences, Kashan, IranDepartment of Gynecology and Obstetrics, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranObjectives: We sought to evaluate the effects of omega-3 and vitamin E co-supplementation on carotid intima-media thickness (CIMT) and inflammatory factors in patients with polycystic ovary syndrome (PCOS). Methods: This randomized, double-blind, placebo-controlled trial was done among 60 women with PCOS. Participants were randomly assigned into two groups (n = 30 each group) and assigned to take either 1000 mg omega-3 plus 400 IU vitamin E supplements or a placebo for 12 weeks. Results: Compared with placebo, omega-3 and vitamin E co-supplementation led to significant decreases in maximum levels of left CIMT (-0.006±0.006 vs. +0.002±0.007 mm, p < 0.001), mean levels of left CIMT (-0.005±0.006 vs. +0.002±0.010 mm, p = 0.010), maximum levels of right CIMT (-0.006±0.010 vs. +0.006±0.010 mm, p = 0.010), and mean levels of right CIMT (-0.005±0.005 vs. +0.001±0.010 mm, p = 0.020). Change in high-sensitivity C-reactive protein (hs-CRP) (-390.6±942.9 vs. +237.0±754.3 ng/mL, p = 0.006) was significantly different between the supplemented patients and placebo group. We did not observe any significant effect in plasma nitric oxide (NO) values following supplementation with omega-3 plus vitamin E compared with the placebo. Conclusions: Co-supplementation with omega-3 and vitamin E for 12 weeks among patients with PCOS had beneficial effects on CIMT and serum hs-CRP values, but unchanged NO values.http://omjournal.org/articleDetails.aspx?coType=1&aId=2398Food SupplementsCarotid Intima-Media ThicknessPolycystic Ovary Syndrome |
| spellingShingle | Hamid Reza Talari Somayyeh Poladchang Yaser Hamidian Mansooreh Samimi Hamid Reza Gilasi Faraneh Afshar Ebrahimi Zatollah Asemi The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome Oman Medical Journal Food Supplements Carotid Intima-Media Thickness Polycystic Ovary Syndrome |
| title | The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome |
| title_full | The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome |
| title_fullStr | The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome |
| title_full_unstemmed | The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome |
| title_short | The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome |
| title_sort | effects of omega 3 and vitamin e co supplementation on carotid intima media thickness and inflammatory factors in patients with polycystic ovary syndrome |
| topic | Food Supplements Carotid Intima-Media Thickness Polycystic Ovary Syndrome |
| url | http://omjournal.org/articleDetails.aspx?coType=1&aId=2398 |
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