Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis
Objective: US women exhibit racial disparities in the lifetime risk of diabetes and related outcomes. Identifying heterogeneity in clinical presentation may assist with reducing racial disparities in diabetes outcomes. We identified clinical phenotypes of diabetes and examined their racial and ethni...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Metabolism Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936822000639 |
| _version_ | 1827987139256647680 |
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| author | Daesung Choi Rebecca Jones-Antwi Mohammed K. Ali Shivani A. Patel |
| author_facet | Daesung Choi Rebecca Jones-Antwi Mohammed K. Ali Shivani A. Patel |
| author_sort | Daesung Choi |
| collection | DOAJ |
| description | Objective: US women exhibit racial disparities in the lifetime risk of diabetes and related outcomes. Identifying heterogeneity in clinical presentation may assist with reducing racial disparities in diabetes outcomes. We identified clinical phenotypes of diabetes and examined their racial and ethnic distribution in US women. Research design and methods: We conducted cluster analysis based on five factors in US women with diagnosed diabetes assessed in the National Health and Nutrition Examination Surveys 1999–2018 (n = 825). Multinomial logistic regression analysis was performed to identify racial and ethnic differences in the distribution of phenotypes. Results: We identified four distinct clinical phenotypes. Two phenotypes, mild age-related and severe insulin-deficient diabetes, each included approximately a third of women. Mild insulin-resistant and severe insulin-resistant diabetes phenotypes accounted for 19.9% and 13.7%, respectively. The distribution of clusters did not differ by race and ethnicity. Conclusions: The prevalence of four clinically distinct diabetes phenotypes identified in US women did not differ by race and ethnicity. |
| first_indexed | 2024-04-09T23:42:16Z |
| format | Article |
| id | doaj.art-0b85b754d7ec47be9988508a1d2ed10b |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-04-09T23:42:16Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-0b85b754d7ec47be9988508a1d2ed10b2023-03-18T04:42:39ZengElsevierMetabolism Open2589-93682023-03-0117100225Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysisDaesung Choi0Rebecca Jones-Antwi1Mohammed K. Ali2Shivani A. Patel3Corresponding author. c/o Emory University, Rollins School of Public Health, 1518 Clifton Road, CNR 7040-J, Atlanta, GA, 30322, USA.; Rollins School of Public Health, Emory University, Atlanta, GA, USARollins School of Public Health, Emory University, Atlanta, GA, USARollins School of Public Health, Emory University, Atlanta, GA, USARollins School of Public Health, Emory University, Atlanta, GA, USAObjective: US women exhibit racial disparities in the lifetime risk of diabetes and related outcomes. Identifying heterogeneity in clinical presentation may assist with reducing racial disparities in diabetes outcomes. We identified clinical phenotypes of diabetes and examined their racial and ethnic distribution in US women. Research design and methods: We conducted cluster analysis based on five factors in US women with diagnosed diabetes assessed in the National Health and Nutrition Examination Surveys 1999–2018 (n = 825). Multinomial logistic regression analysis was performed to identify racial and ethnic differences in the distribution of phenotypes. Results: We identified four distinct clinical phenotypes. Two phenotypes, mild age-related and severe insulin-deficient diabetes, each included approximately a third of women. Mild insulin-resistant and severe insulin-resistant diabetes phenotypes accounted for 19.9% and 13.7%, respectively. The distribution of clusters did not differ by race and ethnicity. Conclusions: The prevalence of four clinically distinct diabetes phenotypes identified in US women did not differ by race and ethnicity.http://www.sciencedirect.com/science/article/pii/S2589936822000639PhenotypeRacial differencesInsulin resistanceHomeostatic model assessment (HOMA)Body mass index (BMI) |
| spellingShingle | Daesung Choi Rebecca Jones-Antwi Mohammed K. Ali Shivani A. Patel Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis Metabolism Open Phenotype Racial differences Insulin resistance Homeostatic model assessment (HOMA) Body mass index (BMI) |
| title | Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis |
| title_full | Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis |
| title_fullStr | Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis |
| title_full_unstemmed | Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis |
| title_short | Do diabetes phenotypes in US women differ by race/ethnicity? A population-based cluster analysis |
| title_sort | do diabetes phenotypes in us women differ by race ethnicity a population based cluster analysis |
| topic | Phenotype Racial differences Insulin resistance Homeostatic model assessment (HOMA) Body mass index (BMI) |
| url | http://www.sciencedirect.com/science/article/pii/S2589936822000639 |
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