Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)
Abstract Background Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalise...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Medicine |
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| Online Access: | https://doi.org/10.1186/s12916-022-02448-4 |
| _version_ | 1818519313602052096 |
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| author | Ekaterina Pazukhina Margarita Andreeva Ekaterina Spiridonova Polina Bobkova Anastasia Shikhaleva Yasmin El-Taravi Mikhail Rumyantsev Aysylu Gamirova Anastasiia Bairashevskaia Polina Petrova Dina Baimukhambetova Maria Pikuza Elina Abdeeva Yulia Filippova Salima Deunezhewa Nikita Nekliudov Polina Bugaeva Nikolay Bulanov Sergey Avdeev Valentina Kapustina Alla Guekht Audrey DunnGalvin Pasquale Comberiati Diego G. Peroni Christian Apfelbacher Jon Genuneit Luis Felipe Reyes Caroline L. H. Brackel Victor Fomin Andrey A. Svistunov Peter Timashev Lyudmila Mazankova Alexandra Miroshina Elmira Samitova Svetlana Borzakova Elena Bondarenko Anatoliy A. Korsunskiy Gail Carson Louise Sigfrid Janet T. Scott Matthew Greenhawt Danilo Buonsenso Malcolm G. Semple John O. Warner Piero Olliaro Dale M. Needham Petr Glybochko Denis Butnaru Ismail M. Osmanov Daniel Munblit Sechenov StopCOVID Research Team |
| author_facet | Ekaterina Pazukhina Margarita Andreeva Ekaterina Spiridonova Polina Bobkova Anastasia Shikhaleva Yasmin El-Taravi Mikhail Rumyantsev Aysylu Gamirova Anastasiia Bairashevskaia Polina Petrova Dina Baimukhambetova Maria Pikuza Elina Abdeeva Yulia Filippova Salima Deunezhewa Nikita Nekliudov Polina Bugaeva Nikolay Bulanov Sergey Avdeev Valentina Kapustina Alla Guekht Audrey DunnGalvin Pasquale Comberiati Diego G. Peroni Christian Apfelbacher Jon Genuneit Luis Felipe Reyes Caroline L. H. Brackel Victor Fomin Andrey A. Svistunov Peter Timashev Lyudmila Mazankova Alexandra Miroshina Elmira Samitova Svetlana Borzakova Elena Bondarenko Anatoliy A. Korsunskiy Gail Carson Louise Sigfrid Janet T. Scott Matthew Greenhawt Danilo Buonsenso Malcolm G. Semple John O. Warner Piero Olliaro Dale M. Needham Petr Glybochko Denis Butnaru Ismail M. Osmanov Daniel Munblit Sechenov StopCOVID Research Team |
| author_sort | Ekaterina Pazukhina |
| collection | DOAJ |
| description | Abstract Background Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC. |
| first_indexed | 2024-12-11T01:22:29Z |
| format | Article |
| id | doaj.art-0b85bc54d14245ba9963a5be30146db2 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-11T01:22:29Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-0b85bc54d14245ba9963a5be30146db22022-12-22T01:25:40ZengBMCBMC Medicine1741-70152022-07-0120111210.1186/s12916-022-02448-4Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)Ekaterina Pazukhina0Margarita Andreeva1Ekaterina Spiridonova2Polina Bobkova3Anastasia Shikhaleva4Yasmin El-Taravi5Mikhail Rumyantsev6Aysylu Gamirova7Anastasiia Bairashevskaia8Polina Petrova9Dina Baimukhambetova10Maria Pikuza11Elina Abdeeva12Yulia Filippova13Salima Deunezhewa14Nikita Nekliudov15Polina Bugaeva16Nikolay Bulanov17Sergey Avdeev18Valentina Kapustina19Alla Guekht20Audrey DunnGalvin21Pasquale Comberiati22Diego G. Peroni23Christian Apfelbacher24Jon Genuneit25Luis Felipe Reyes26Caroline L. H. Brackel27Victor Fomin28Andrey A. Svistunov29Peter Timashev30Lyudmila Mazankova31Alexandra Miroshina32Elmira Samitova33Svetlana Borzakova34Elena Bondarenko35Anatoliy A. Korsunskiy36Gail Carson37Louise Sigfrid38Janet T. Scott39Matthew Greenhawt40Danilo Buonsenso41Malcolm G. Semple42John O. Warner43Piero Olliaro44Dale M. Needham45Petr Glybochko46Denis Butnaru47Ismail M. Osmanov48Daniel Munblit49Sechenov StopCOVID Research TeamLaboratory of Health Economics, Institute of Applied Economic Studies, The Russian Presidential Academy of National Economy and Public AdministrationDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University)Clinic of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University)Department of Internal Medicine №1, Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University)Research and Clinical Center for NeuropsychiatryDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Clinical and Experimental Medicine, Section of Pediatrics, University of PisaDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of PisaInstitute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University MagdeburgPediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig UniversityUniversidad de La SabanaDepartment of Pediatric Pulmonology, Emma Children’s Hospital, Amsterdam University Medical CentersSechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University)Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationZA Bashlyaeva Children’s Municipal Clinical HospitalRussian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationPirogov Russian National Research Medical UniversityDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Nuffield Department of Medicine, ISARIC Global Support Centre, University of OxfordNuffield Department of Medicine, ISARIC Global Support Centre, University of OxfordMRC-University of Glasgow Centre for Virus ResearchDepartment of Pediatrics, Section of Allergy/Immunology, Children’s Hospital Colorado, University of Colorado School of MedicineDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSHealth Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of LiverpoolInflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College LondonNuffield Department of Medicine, ISARIC Global Support Centre, University of OxfordOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins UniversitySechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Pirogov Russian National Research Medical UniversityDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)Abstract Background Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.https://doi.org/10.1186/s12916-022-02448-4AdultsChildrenCOVID-19COVID-19 sequelaeLong COVIDPost-acute sequelae of SARS-CoV-2 infection |
| spellingShingle | Ekaterina Pazukhina Margarita Andreeva Ekaterina Spiridonova Polina Bobkova Anastasia Shikhaleva Yasmin El-Taravi Mikhail Rumyantsev Aysylu Gamirova Anastasiia Bairashevskaia Polina Petrova Dina Baimukhambetova Maria Pikuza Elina Abdeeva Yulia Filippova Salima Deunezhewa Nikita Nekliudov Polina Bugaeva Nikolay Bulanov Sergey Avdeev Valentina Kapustina Alla Guekht Audrey DunnGalvin Pasquale Comberiati Diego G. Peroni Christian Apfelbacher Jon Genuneit Luis Felipe Reyes Caroline L. H. Brackel Victor Fomin Andrey A. Svistunov Peter Timashev Lyudmila Mazankova Alexandra Miroshina Elmira Samitova Svetlana Borzakova Elena Bondarenko Anatoliy A. Korsunskiy Gail Carson Louise Sigfrid Janet T. Scott Matthew Greenhawt Danilo Buonsenso Malcolm G. Semple John O. Warner Piero Olliaro Dale M. Needham Petr Glybochko Denis Butnaru Ismail M. Osmanov Daniel Munblit Sechenov StopCOVID Research Team Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) BMC Medicine Adults Children COVID-19 COVID-19 sequelae Long COVID Post-acute sequelae of SARS-CoV-2 infection |
| title | Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) |
| title_full | Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) |
| title_fullStr | Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) |
| title_full_unstemmed | Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) |
| title_short | Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) |
| title_sort | prevalence and risk factors of post covid 19 condition in adults and children at 6 and 12 months after hospital discharge a prospective cohort study in moscow stopcovid |
| topic | Adults Children COVID-19 COVID-19 sequelae Long COVID Post-acute sequelae of SARS-CoV-2 infection |
| url | https://doi.org/10.1186/s12916-022-02448-4 |
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