The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a chronic disease that has become a global public health problem. Studies on T2DM prevention and treatment mostly focus on discovering therapeutic drugs. Artemisinin and its derivatives were originally used as antimalarial treatments. In recent years, the roles of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.585487/full |
| _version_ | 1818435593715056640 |
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| author | Ya-yi Jiang Jia-cheng Shui Bo-xun Zhang Jia-wei Chin Ren-song Yue |
| author_facet | Ya-yi Jiang Jia-cheng Shui Bo-xun Zhang Jia-wei Chin Ren-song Yue |
| author_sort | Ya-yi Jiang |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is a chronic disease that has become a global public health problem. Studies on T2DM prevention and treatment mostly focus on discovering therapeutic drugs. Artemisinin and its derivatives were originally used as antimalarial treatments. In recent years, the roles of artemisinins in T2DM have attracted much attention. Artemisinin treatments not only attenuate insulin resistance and restore islet ß-cell function in T2DM but also have potential therapeutic effects on diabetic complications, including diabetic kidney disease, cognitive impairment, diabetic retinopathy, and diabetic cardiovascular disease. Many in vitro and in vivo experiments have confirmed the therapeutic utility of artemisinin and its derivatives on T2DM, but no article has systematically demonstrated the specific role artemisinin plays in the treatment of T2DM. This review summarizes the potential therapeutic effects and mechanism of artemisinin and its derivatives in T2DM and associated complications, providing a reference for subsequent related research. |
| first_indexed | 2024-12-14T16:55:21Z |
| format | Article |
| id | doaj.art-0b8ece072c09440c919d35a23eba9f6c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T16:55:21Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0b8ece072c09440c919d35a23eba9f6c2022-12-21T22:53:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-11-011110.3389/fphar.2020.585487585487The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes MellitusYa-yi Jiang0Jia-cheng Shui1Bo-xun Zhang2Jia-wei Chin3Ren-song Yue4Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, China Academy of Chinese Medical Sciences, Beijing, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaType 2 diabetes mellitus (T2DM) is a chronic disease that has become a global public health problem. Studies on T2DM prevention and treatment mostly focus on discovering therapeutic drugs. Artemisinin and its derivatives were originally used as antimalarial treatments. In recent years, the roles of artemisinins in T2DM have attracted much attention. Artemisinin treatments not only attenuate insulin resistance and restore islet ß-cell function in T2DM but also have potential therapeutic effects on diabetic complications, including diabetic kidney disease, cognitive impairment, diabetic retinopathy, and diabetic cardiovascular disease. Many in vitro and in vivo experiments have confirmed the therapeutic utility of artemisinin and its derivatives on T2DM, but no article has systematically demonstrated the specific role artemisinin plays in the treatment of T2DM. This review summarizes the potential therapeutic effects and mechanism of artemisinin and its derivatives in T2DM and associated complications, providing a reference for subsequent related research.https://www.frontiersin.org/articles/10.3389/fphar.2020.585487/fullArtemisininartemisinin derivativestype 2 diabetescomplicationstherapypharmacology |
| spellingShingle | Ya-yi Jiang Jia-cheng Shui Bo-xun Zhang Jia-wei Chin Ren-song Yue The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus Frontiers in Pharmacology Artemisinin artemisinin derivatives type 2 diabetes complications therapy pharmacology |
| title | The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus |
| title_full | The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus |
| title_fullStr | The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus |
| title_short | The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus |
| title_sort | potential roles of artemisinin and its derivatives in the treatment of type 2 diabetes mellitus |
| topic | Artemisinin artemisinin derivatives type 2 diabetes complications therapy pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.585487/full |
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