The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases
Mitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete mitochondria by autophagy, which is critical for the functional integrity of the entire mitochondrial network and cell survival. Because dysfunction of mitophagy is closely related to many diseases, it is importa...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2021-09-01
|
| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304220301161 |
| _version_ | 1797724591838199808 |
|---|---|
| author | Weilin Zhang |
| author_facet | Weilin Zhang |
| author_sort | Weilin Zhang |
| collection | DOAJ |
| description | Mitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete mitochondria by autophagy, which is critical for the functional integrity of the entire mitochondrial network and cell survival. Because dysfunction of mitophagy is closely related to many diseases, it is important to study the specific molecular mechanism and pathophysiological significance of mitophagy. FUN14 domain-containing 1 (FUNDC1) is a newly identified mitochondrial outer membrane protein that induces receptor-mediated mitophagy by its interaction with LC3 during hypoxia. The expression, phosphorylation, regulation and significance of FUNDC1 are reviewed in the context of a large number of pathophysiological conditions. Emerging evidence has demonstrated that levels and phosphorylation states of FUNDC1 are closely related to occurrence, progression and prognosis of various diseases including heart diseases and cancers, indicating that FUNDC1 may serve as a promising biomarker and potential therapeutic target. |
| first_indexed | 2024-03-12T10:19:19Z |
| format | Article |
| id | doaj.art-0b8f16f8fe454faa8a2e7abf9bf16ea1 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T10:19:19Z |
| publishDate | 2021-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-0b8f16f8fe454faa8a2e7abf9bf16ea12023-09-02T10:14:09ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-09-0185640654The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseasesWeilin Zhang0State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100864, PR ChinaMitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete mitochondria by autophagy, which is critical for the functional integrity of the entire mitochondrial network and cell survival. Because dysfunction of mitophagy is closely related to many diseases, it is important to study the specific molecular mechanism and pathophysiological significance of mitophagy. FUN14 domain-containing 1 (FUNDC1) is a newly identified mitochondrial outer membrane protein that induces receptor-mediated mitophagy by its interaction with LC3 during hypoxia. The expression, phosphorylation, regulation and significance of FUNDC1 are reviewed in the context of a large number of pathophysiological conditions. Emerging evidence has demonstrated that levels and phosphorylation states of FUNDC1 are closely related to occurrence, progression and prognosis of various diseases including heart diseases and cancers, indicating that FUNDC1 may serve as a promising biomarker and potential therapeutic target.http://www.sciencedirect.com/science/article/pii/S2352304220301161AutophagyBiomarkerFUNDC1Heart diseasesHypoxiaMitochondria |
| spellingShingle | Weilin Zhang The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases Genes and Diseases Autophagy Biomarker FUNDC1 Heart diseases Hypoxia Mitochondria |
| title | The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases |
| title_full | The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases |
| title_fullStr | The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases |
| title_full_unstemmed | The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases |
| title_short | The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases |
| title_sort | mitophagy receptor fun14 domain containing 1 fundc1 a promising biomarker and potential therapeutic target of human diseases |
| topic | Autophagy Biomarker FUNDC1 Heart diseases Hypoxia Mitochondria |
| url | http://www.sciencedirect.com/science/article/pii/S2352304220301161 |
| work_keys_str_mv | AT weilinzhang themitophagyreceptorfun14domaincontaining1fundc1apromisingbiomarkerandpotentialtherapeutictargetofhumandiseases AT weilinzhang mitophagyreceptorfun14domaincontaining1fundc1apromisingbiomarkerandpotentialtherapeutictargetofhumandiseases |