Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral cancer

Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral cancer

Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+-dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle. Mutations of IDH1 and IDH2 have been identified in patients with glioma, leukemia, and other c...

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Bibliographic Details
Main Authors: Jen-Yang Tang, Chun-Chi Chang, Pei-Chin Lin, Jan-Gowth Chang
Format: Article
Language:English
Published: Wiley 2012-03-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
HRM
IDH
Leukemia
Mutation
Oral cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1607551X11002464

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