MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway

MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway

Background This study explored the function and mechanism of miR-486-5p in HSFBs. Methods Qualitative real-time-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-486-5p in HS and hypertrophic scar fibroblasts (HSFBs). Viability, migration, invasion ability, apoptosis,...

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Bibliographic Details
Main Author: Yifeng Xiao
Format: Article
Language:English
Published: Taylor & Francis Group 2021-11-01
Series:Journal of Dermatological Treatment
Subjects:
hypertrophic scar
fibroblasts
mir-486-5p
igf1
pi3k/akt
Online Access:http://dx.doi.org/10.1080/09546634.2020.1728210

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