Local analgesic effect of tramadol is not mediated by opioid receptors in early postoperative pain in rats

BACKGROUND AND OBJECTIVES: Tramadol is known as a central acting analgesic drug, used for the treatment of moderate to severe pain. Local analgesic effect has been demonstrated, in part due to local anesthetic-like effect, but other mechanisms remain unclear. The role of peripheral opioid receptors...

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Bibliographic Details
Main Authors: Angela Maria Sousa, Hazem Adel Ashmawi
Format: Article
Language:English
Published: Sociedade Brasileira de Anestesiologia 2015-06-01
Series:Revista Brasileira de Anestesiologia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942015000300186&lng=en&tlng=en