Does dietary intake of acrylamide affect hydroxyproline levels? An animal study
Acrylamide is a chemical that occurs due to high temperatures during cooking. It consists of an amino acid found in foods and sugars. Studies have shown that cancer formation occurs within the scope of oxidant reagents and DNA damage due to exposure to acrylamide. Our study aims to examine the effec...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2022-12-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=11379 |
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| author | Tugba Agbektas Ozhan Pazarci Ayca Tas Nese Keklikcioglu Cakmak Seyran Kilinc Yavuz Silig |
| author_facet | Tugba Agbektas Ozhan Pazarci Ayca Tas Nese Keklikcioglu Cakmak Seyran Kilinc Yavuz Silig |
| author_sort | Tugba Agbektas |
| collection | DOAJ |
| description | Acrylamide is a chemical that occurs due to high temperatures during cooking. It consists of an amino acid found in foods and sugars. Studies have shown that cancer formation occurs within the scope of oxidant reagents and DNA damage due to exposure to acrylamide. Our study aims to examine the effects of dietary acrylamide intake on plasma hydroxyproline levels in rats. In this study, 4 groups were formed with 8 rats in each group (total number=32). Blood samples were collected on days 14 and 28. Acrylamide solution was applied to each rat in the treatment group by gastric gavage process at 5 mg/kg three times a week. Hydroxyproline levels in rats' plasma samples were measured. The median (IQR) hydroxyproline levels were 7.40(2.45) µg/L in group 1 (14. days control group) and 7.98(3.34) µg/L in group 2 (14. days acrylamide applied) who received acrylamide. The mean hydroxyproline levels were 7.25(1.96) µg/L in group 3 (28. days control group) and 9.76(2.64) µg/L in group 4 (28. days acrylamide applied) who received acrylamide. No difference was observed between the groups. Dietary acrylamide intake did not have a significant effect on hydroxyproline levels at the application dose and duration in our study. [Med-Science 2022; 11(4.000): 1478-81] |
| first_indexed | 2024-03-08T06:47:48Z |
| format | Article |
| id | doaj.art-0b908a5e90b64716a2aa2b49a7b97895 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:47:48Z |
| publishDate | 2022-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-0b908a5e90b64716a2aa2b49a7b978952024-02-03T07:29:07ZengSociety of Turaz BilimMedicine Science2147-06342022-12-0111414788110.5455/medscience.2022.04.08211379Does dietary intake of acrylamide affect hydroxyproline levels? An animal studyTugba Agbektas0Ozhan Pazarci1Ayca Tas2Nese Keklikcioglu Cakmak3Seyran Kilinc4Yavuz Silig5Sivas Cumhuriyet University Faculty of Medicine, Department of Biochemistry Adana City Training and Research Hospital, Department of Orthopedics and Traumatology Sivas Cumhuriyet University, Faculty of Health Sciences, Department of Nutrition and Dietetics Sivas Cumhuriyet University, Faculty of Engineering, Department of Chemical Engineering Sivas Cumhuriyet University Faculty of Medicine, Department of Orthopedics and Traumatology Sivas Cumhuriyet University Faculty of Medicine, Department of BiochemistryAcrylamide is a chemical that occurs due to high temperatures during cooking. It consists of an amino acid found in foods and sugars. Studies have shown that cancer formation occurs within the scope of oxidant reagents and DNA damage due to exposure to acrylamide. Our study aims to examine the effects of dietary acrylamide intake on plasma hydroxyproline levels in rats. In this study, 4 groups were formed with 8 rats in each group (total number=32). Blood samples were collected on days 14 and 28. Acrylamide solution was applied to each rat in the treatment group by gastric gavage process at 5 mg/kg three times a week. Hydroxyproline levels in rats' plasma samples were measured. The median (IQR) hydroxyproline levels were 7.40(2.45) µg/L in group 1 (14. days control group) and 7.98(3.34) µg/L in group 2 (14. days acrylamide applied) who received acrylamide. The mean hydroxyproline levels were 7.25(1.96) µg/L in group 3 (28. days control group) and 9.76(2.64) µg/L in group 4 (28. days acrylamide applied) who received acrylamide. No difference was observed between the groups. Dietary acrylamide intake did not have a significant effect on hydroxyproline levels at the application dose and duration in our study. [Med-Science 2022; 11(4.000): 1478-81]http://www.ejmanager.com/fulltextpdf.php?mno=11379hydroxyprolineacrylamideratserum level |
| spellingShingle | Tugba Agbektas Ozhan Pazarci Ayca Tas Nese Keklikcioglu Cakmak Seyran Kilinc Yavuz Silig Does dietary intake of acrylamide affect hydroxyproline levels? An animal study Medicine Science hydroxyproline acrylamide rat serum level |
| title | Does dietary intake of acrylamide affect hydroxyproline levels? An animal study |
| title_full | Does dietary intake of acrylamide affect hydroxyproline levels? An animal study |
| title_fullStr | Does dietary intake of acrylamide affect hydroxyproline levels? An animal study |
| title_full_unstemmed | Does dietary intake of acrylamide affect hydroxyproline levels? An animal study |
| title_short | Does dietary intake of acrylamide affect hydroxyproline levels? An animal study |
| title_sort | does dietary intake of acrylamide affect hydroxyproline levels an animal study |
| topic | hydroxyproline acrylamide rat serum level |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=11379 |
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