Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report
Hepatosplenic T-cell lymphoma (HSTCL) is a rare non-Hodgkin lymphoma, marked by liver, spleen, and bone marrow sinusoidal infiltration, with an aggressive clinical course, which represents a difficult diagnostic task for clinicians and pathologists. Another equally severe and challenging condition i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2014-12-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | http://www.revistas.usp.br/autopsy/article/view/98462 |
| _version_ | 1823939894960979968 |
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| author | Vitor Ribeiro Paes Patrícia Picciarelli de Lima Sheila Aparecida Coelho Siqueira |
| author_facet | Vitor Ribeiro Paes Patrícia Picciarelli de Lima Sheila Aparecida Coelho Siqueira |
| author_sort | Vitor Ribeiro Paes |
| collection | DOAJ |
| description | Hepatosplenic T-cell lymphoma (HSTCL) is a rare non-Hodgkin lymphoma, marked by liver, spleen, and bone marrow sinusoidal infiltration, with an aggressive clinical course, which represents a difficult diagnostic task for clinicians and pathologists. Another equally severe and challenging condition is the hemophagocytic lymphohistiocytosis (also called hemophagocytic syndrome [HS]), which is often associated with hematologic malignancies and infectious diseases. The authors report the case of a 56-year-old woman diagnosed with HSTCL based on bone marrow aspirate flow cytometry and skin biopsy. The patient underwent a cycle of chemotherapy but the outcome was unfavorable with multiple organ failure. The laboratory analysis was consistent with HS. The autopsy confirmed both the remaining lymphoma in the pulmonary vessels and the hemophagocytic cells in the spleen and bone marrow. |
| first_indexed | 2024-12-17T04:05:47Z |
| format | Article |
| id | doaj.art-0b92104bfef345d49d244413b0029892 |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-17T04:05:47Z |
| publishDate | 2014-12-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-0b92104bfef345d49d244413b00298922022-12-21T22:04:20ZengUniversity of São PauloAutopsy and Case Reports2236-19602014-12-014410.4322/acr.%y.9846288480Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case reportVitor Ribeiro Paes0Patrícia Picciarelli de Lima1Sheila Aparecida Coelho Siqueira2Pathological Anatomical Division - Hospital das Clínicas - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SPPathological Anatomical Division - Hospital das Clínicas - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SPPathological Anatomical Division - Hospital das Clínicas - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SPHepatosplenic T-cell lymphoma (HSTCL) is a rare non-Hodgkin lymphoma, marked by liver, spleen, and bone marrow sinusoidal infiltration, with an aggressive clinical course, which represents a difficult diagnostic task for clinicians and pathologists. Another equally severe and challenging condition is the hemophagocytic lymphohistiocytosis (also called hemophagocytic syndrome [HS]), which is often associated with hematologic malignancies and infectious diseases. The authors report the case of a 56-year-old woman diagnosed with HSTCL based on bone marrow aspirate flow cytometry and skin biopsy. The patient underwent a cycle of chemotherapy but the outcome was unfavorable with multiple organ failure. The laboratory analysis was consistent with HS. The autopsy confirmed both the remaining lymphoma in the pulmonary vessels and the hemophagocytic cells in the spleen and bone marrow.http://www.revistas.usp.br/autopsy/article/view/98462LymphomaT-cellPeripheralLymphohistiocytosisHemophagocyticAutopsy |
| spellingShingle | Vitor Ribeiro Paes Patrícia Picciarelli de Lima Sheila Aparecida Coelho Siqueira Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report Autopsy and Case Reports Lymphoma T-cell Peripheral Lymphohistiocytosis Hemophagocytic Autopsy |
| title | Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report |
| title_full | Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report |
| title_fullStr | Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report |
| title_full_unstemmed | Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report |
| title_short | Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report |
| title_sort | hemophagocytic lymphohistiocytosis associated with hepatosplenic t cell lymphoma case report |
| topic | Lymphoma T-cell Peripheral Lymphohistiocytosis Hemophagocytic Autopsy |
| url | http://www.revistas.usp.br/autopsy/article/view/98462 |
| work_keys_str_mv | AT vitorribeiropaes hemophagocyticlymphohistiocytosisassociatedwithhepatosplenictcelllymphomacasereport AT patriciapicciarellidelima hemophagocyticlymphohistiocytosisassociatedwithhepatosplenictcelllymphomacasereport AT sheilaaparecidacoelhosiqueira hemophagocyticlymphohistiocytosisassociatedwithhepatosplenictcelllymphomacasereport |