Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder
Lymphoepithelioma-like carcinoma of the urinary bladder (LELCB) is a rare variant of infiltrating urothelial carcinoma. We report a case of LELCB in a 43-year-old man. Ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-03-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/445049 |
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| author | Takashi Nagai Taku Naiki Noriyasu Kawai Keitaro Iida Toshiki Etani Ryosuke Ando Shuzo Hamamoto Yosuke Sugiyama Atsushi Okada Kentaro Mizuno Yukihiro Umemoto Takahiro Yasui |
| author_facet | Takashi Nagai Taku Naiki Noriyasu Kawai Keitaro Iida Toshiki Etani Ryosuke Ando Shuzo Hamamoto Yosuke Sugiyama Atsushi Okada Kentaro Mizuno Yukihiro Umemoto Takahiro Yasui |
| author_sort | Takashi Nagai |
| collection | DOAJ |
| description | Lymphoepithelioma-like carcinoma of the urinary bladder (LELCB) is a rare variant of infiltrating urothelial carcinoma. We report a case of LELCB in a 43-year-old man. Ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of the trigone. Transurethral resection of the bladder tumors was performed and pathological analysis revealed undifferentiated carcinoma. We therefore performed radical cystectomy and urinary diversion. Immunohistochemically the tumor cells were positive for cytokeratin, but negative for Epstein-Barr virus-encoded small RNA in situ hybridization as found for previous cases of LELCB. The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion. For adjuvant systemic chemotherapy, three courses of cisplatin were administered. The patient subsequently became free of cancer 72 months postoperatively. Based on the literature, pure or predominant LELCB types show favorable prognoses due to their sensitivity to chemotherapy or radiotherapy. An analysis of the apparent diffusion coefficient (ADC) values of bladder tumors examined in our institution revealed that the ADC value measured for this LELCB was relatively low compared to conventional urothelial carcinomas. This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB. |
| first_indexed | 2024-04-13T16:48:58Z |
| format | Article |
| id | doaj.art-0b979708e42949589d5388695d5f20bc |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T16:48:58Z |
| publishDate | 2016-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-0b979708e42949589d5388695d5f20bc2022-12-22T02:39:00ZengKarger PublishersCase Reports in Oncology1662-65752016-03-019118819410.1159/000445049445049Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary BladderTakashi NagaiTaku NaikiNoriyasu KawaiKeitaro IidaToshiki EtaniRyosuke AndoShuzo HamamotoYosuke SugiyamaAtsushi OkadaKentaro MizunoYukihiro UmemotoTakahiro YasuiLymphoepithelioma-like carcinoma of the urinary bladder (LELCB) is a rare variant of infiltrating urothelial carcinoma. We report a case of LELCB in a 43-year-old man. Ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of the trigone. Transurethral resection of the bladder tumors was performed and pathological analysis revealed undifferentiated carcinoma. We therefore performed radical cystectomy and urinary diversion. Immunohistochemically the tumor cells were positive for cytokeratin, but negative for Epstein-Barr virus-encoded small RNA in situ hybridization as found for previous cases of LELCB. The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion. For adjuvant systemic chemotherapy, three courses of cisplatin were administered. The patient subsequently became free of cancer 72 months postoperatively. Based on the literature, pure or predominant LELCB types show favorable prognoses due to their sensitivity to chemotherapy or radiotherapy. An analysis of the apparent diffusion coefficient (ADC) values of bladder tumors examined in our institution revealed that the ADC value measured for this LELCB was relatively low compared to conventional urothelial carcinomas. This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB.http://www.karger.com/Article/FullText/445049Lymphoepithelioma-like carcinomaApparent diffusion coefficient valueUrinary bladderEpstein-Barr virus |
| spellingShingle | Takashi Nagai Taku Naiki Noriyasu Kawai Keitaro Iida Toshiki Etani Ryosuke Ando Shuzo Hamamoto Yosuke Sugiyama Atsushi Okada Kentaro Mizuno Yukihiro Umemoto Takahiro Yasui Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder Case Reports in Oncology Lymphoepithelioma-like carcinoma Apparent diffusion coefficient value Urinary bladder Epstein-Barr virus |
| title | Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder |
| title_full | Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder |
| title_fullStr | Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder |
| title_full_unstemmed | Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder |
| title_short | Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder |
| title_sort | pure lymphoepithelioma like carcinoma originating from the urinary bladder |
| topic | Lymphoepithelioma-like carcinoma Apparent diffusion coefficient value Urinary bladder Epstein-Barr virus |
| url | http://www.karger.com/Article/FullText/445049 |
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