Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

Multiple sclerosis (MS) is an immune-mediated inflammatory disease that leads to demyelination and neuronal loss in the central nervous system. Immune cells of lymphoid and myeloid origin play a significant role in the initiation and amplification of neuronal inflammation in MS. STAT3 signaling play...

Full description

Bibliographic Details
Main Authors: Khalid Alhazzani, Sheikh F. Ahmad, Naif O. Al-Harbi, Sabry M. Attia, Saleh A. Bakheet, Wedad Sarawi, Saleh A. Alqarni, Mohammad Algahtani, Ahmed Nadeem
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
multiple sclerosis
granulocytes
CD4+ T cells
STAT3 inhibition
IL-17A
iNOS
Online Access:https://www.mdpi.com/1999-4923/13/7/925

Similar Items

Similar Items