Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum.
ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity for ileum m...
Main Authors: | Alper Okyar, Enza Piccolo, Constance Ahowesso, Elisabeth Filipski, Virginie Hossard, Catherine Guettier, Rosanna La Sorda, Nicola Tinari, Stefano Iacobelli, Francis Lévi |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3108586?pdf=render |
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