Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord

Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord

Intrathecal administration of brain derived neurotrophic factor (BDNF) induces long-term potentiation (LTP) and generates long-lasting central sensitization in spinal cord thus mimicking chronic pain, but the relevance of these observations to chronic pain mechanisms is uncertain. Since C-fiber acti...

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Bibliographic Details
Main Authors: Jeffri Retamal, Andrea Reyes, Paulina Ramirez, David Bravo, Alejandro Hernandez, Teresa Pelissier, Luis Villanueva, Luis Constandil
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
subcutaneous electrical stimulation
hyperalgesia
C-reflex
windup
brain-derived neurotrophic factor
cyclotraxin-B
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01143/full

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