Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy
Abstract Objective To analyze the correlation between relevant factors and radiation‐induced nasopharyngeal ulcer (RINU) in primary nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiation therapy (IMRT). Methods Clinical data were collected for 599 patients with newly diagnosed NPC...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.365 |
| _version_ | 1818455291326365696 |
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| author | Zhaodong Fei Taojun Chen Xiufang Qiu Chuanben Chen |
| author_facet | Zhaodong Fei Taojun Chen Xiufang Qiu Chuanben Chen |
| author_sort | Zhaodong Fei |
| collection | DOAJ |
| description | Abstract Objective To analyze the correlation between relevant factors and radiation‐induced nasopharyngeal ulcer (RINU) in primary nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiation therapy (IMRT). Methods Clinical data were collected for 599 patients with newly diagnosed NPC who had completed IMRT. The entire cohort was randomly divided into two subgroups. The relationship between RINU and IMRT dose‐volume were statistically analyzed with ROC curves and the Chi‐square test. Nutritional status during and after treatment was compared between patients with vs without RINU. Results The results obtained showed that dose‐volume had no effect on the incidence of RINU (P > .05). Nutrition‐related parameters differed significantly between patients with vs without RINU (P < .05). Conclusion The results obtained show that the incidence of RINU is not related to IMRT dose‐volume in the treatment of primary NPC. The incidence of RINU was found to be related to nutritional status during and after radiation therapy. Level of Evidence 2a |
| first_indexed | 2024-12-14T22:08:26Z |
| format | Article |
| id | doaj.art-0b9d6c7f2e144b7f9b779107be29684f |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-12-14T22:08:26Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-0b9d6c7f2e144b7f9b779107be29684f2022-12-21T22:45:48ZengWileyLaryngoscope Investigative Otolaryngology2378-80382020-04-015222823410.1002/lio2.365Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapyZhaodong Fei0Taojun Chen1Xiufang Qiu2Chuanben Chen3Department of Radiotherapy Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou Fujian Province ChinaDepartment of Radiotherapy Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou Fujian Province ChinaDepartment of Radiotherapy Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou Fujian Province ChinaDepartment of Radiotherapy Fujian Cancer Hospital, Fujian Medical University Cancer Hospital Fuzhou Fujian Province ChinaAbstract Objective To analyze the correlation between relevant factors and radiation‐induced nasopharyngeal ulcer (RINU) in primary nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiation therapy (IMRT). Methods Clinical data were collected for 599 patients with newly diagnosed NPC who had completed IMRT. The entire cohort was randomly divided into two subgroups. The relationship between RINU and IMRT dose‐volume were statistically analyzed with ROC curves and the Chi‐square test. Nutritional status during and after treatment was compared between patients with vs without RINU. Results The results obtained showed that dose‐volume had no effect on the incidence of RINU (P > .05). Nutrition‐related parameters differed significantly between patients with vs without RINU (P < .05). Conclusion The results obtained show that the incidence of RINU is not related to IMRT dose‐volume in the treatment of primary NPC. The incidence of RINU was found to be related to nutritional status during and after radiation therapy. Level of Evidence 2ahttps://doi.org/10.1002/lio2.365dose‐volumeintensity‐modulated radiation therapynasopharyngeal carcinomanutrition‐related parametersradiation‐induced nasopharyngeal ulcer |
| spellingShingle | Zhaodong Fei Taojun Chen Xiufang Qiu Chuanben Chen Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy Laryngoscope Investigative Otolaryngology dose‐volume intensity‐modulated radiation therapy nasopharyngeal carcinoma nutrition‐related parameters radiation‐induced nasopharyngeal ulcer |
| title | Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy |
| title_full | Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy |
| title_fullStr | Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy |
| title_full_unstemmed | Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy |
| title_short | Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy |
| title_sort | effect of relevant factors on radiation induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity modulated radiation therapy |
| topic | dose‐volume intensity‐modulated radiation therapy nasopharyngeal carcinoma nutrition‐related parameters radiation‐induced nasopharyngeal ulcer |
| url | https://doi.org/10.1002/lio2.365 |
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