Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
Abstract Background Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02485-1 |
| _version_ | 1818462091814633472 |
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| author | Saul Martínez-Horta Helena Bejr-Kasem Andrea Horta-Barba Berta Pascual-Sedano Diego Santos-García Teresa de Deus-Fonticoba Silvia Jesús Miquel Aguilar Lluis Planellas Juan García-Caldentey Nuria Caballol Bárbara Vives-Pastor Jorge Hernández-Vara Iria Cabo-Lopez Lydia López-Manzanares Isabel González-Aramburu Maria Asunción Ávila-Rivera Maria Jose Catalán Luis Manuel López-Díaz Victor Puente Jose Manuel García-Moreno Carmen Borrué Berta Solano-Vila Maria Álvarez-Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo-Padilla Juan Carlos Martínez-Castrillo Pilar Sánchez-Alonso Maria Gema Alonso-Losada Nuria López-Ariztegui Itziar Gastón Marta Blázquez-Estrada Manual Seijo-Martínez Javier Rúiz-Martínez Caridad Valero-Merino Monica Kurtis Oriol de Fábregues-Boixar Jessica González-Ardura Cristina Prieto-Jurczynska Pablo Martinez-Martin Pablo Mir Jaime Kulisevsky COPPADIS Study Group |
| author_facet | Saul Martínez-Horta Helena Bejr-Kasem Andrea Horta-Barba Berta Pascual-Sedano Diego Santos-García Teresa de Deus-Fonticoba Silvia Jesús Miquel Aguilar Lluis Planellas Juan García-Caldentey Nuria Caballol Bárbara Vives-Pastor Jorge Hernández-Vara Iria Cabo-Lopez Lydia López-Manzanares Isabel González-Aramburu Maria Asunción Ávila-Rivera Maria Jose Catalán Luis Manuel López-Díaz Victor Puente Jose Manuel García-Moreno Carmen Borrué Berta Solano-Vila Maria Álvarez-Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo-Padilla Juan Carlos Martínez-Castrillo Pilar Sánchez-Alonso Maria Gema Alonso-Losada Nuria López-Ariztegui Itziar Gastón Marta Blázquez-Estrada Manual Seijo-Martínez Javier Rúiz-Martínez Caridad Valero-Merino Monica Kurtis Oriol de Fábregues-Boixar Jessica González-Ardura Cristina Prieto-Jurczynska Pablo Martinez-Martin Pablo Mir Jaime Kulisevsky COPPADIS Study Group |
| author_sort | Saul Martínez-Horta |
| collection | DOAJ |
| description | Abstract Background Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD. |
| first_indexed | 2024-12-14T23:56:32Z |
| format | Article |
| id | doaj.art-0b9e0017c31e42568071f0f6b4ae9a90 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-14T23:56:32Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-0b9e0017c31e42568071f0f6b4ae9a902022-12-21T22:43:06ZengBMCBMC Neurology1471-23772021-12-0121111010.1186/s12883-021-02485-1Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s diseaseSaul Martínez-Horta0Helena Bejr-Kasem1Andrea Horta-Barba2Berta Pascual-Sedano3Diego Santos-García4Teresa de Deus-Fonticoba5Silvia Jesús6Miquel Aguilar7Lluis Planellas8Juan García-Caldentey9Nuria Caballol10Bárbara Vives-Pastor11Jorge Hernández-Vara12Iria Cabo-Lopez13Lydia López-Manzanares14Isabel González-Aramburu15Maria Asunción Ávila-Rivera16Maria Jose Catalán17Luis Manuel López-Díaz18Victor Puente19Jose Manuel García-Moreno20Carmen Borrué21Berta Solano-Vila22Maria Álvarez-Sauco23Lydia Vela24Sonia Escalante25Esther Cubo26Francisco Carrillo-Padilla27Juan Carlos Martínez-Castrillo28Pilar Sánchez-Alonso29Maria Gema Alonso-Losada30Nuria López-Ariztegui31Itziar Gastón32Marta Blázquez-Estrada33Manual Seijo-Martínez34Javier Rúiz-Martínez35Caridad Valero-Merino36Monica Kurtis37Oriol de Fábregues-Boixar38Jessica González-Ardura39Cristina Prieto-Jurczynska40Pablo Martinez-Martin41Pablo Mir42Jaime Kulisevsky43COPPADIS Study GroupMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant PauMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant PauMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant PauMovement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant PauCHUAC, Complejo Hospitalario Universitario de A CoruñaComplejo Hospitalario Universitario de Ferrol (CHUF)Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED)Hospital Universitari Mutua de TerrassaHospital Clínic de BarcelonaHospital Quiron Palmaplanas, Clínica Rotger y Centro Neurológico Oms 42Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan DespíHospital Universitario Son EspasesNeurology Department and Neurodegenerative Diseases Research GroupComplejo Hospitalario Universitario de Pontevedra (CHOP)Hospital La PrincesaHospital Universitario Marqués de ValdecillaConsorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan DespíHospital Universitario Clínico San CarlosHospital Da Costa de BurelaHospital del MarHospital Universitario Virgen MacarenaHospital Universitario Infanta Sofía, San Sebastián de los ReyesHospital Universitari Josep Trueta y Hospital Santa CaterinaHospital General Universitario de ElcheFundación Hospital de AlcorcónHospital de Tortosa Verge de la Cinta (HTVC)Complejo Asistencial Universitario de BurgosUnidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica. Hospital Universitario de CanariasHospital Ramón y CajalHospital Universitario Puerta de HierroHospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI)Servicio de Neurología, Complejo Hospitalario Universitario de ToledoComplejo Hospitalario de NavarraHospital Universitario Central de AsturiasComplejo Hospitalario Universitario de Pontevedra (CHOP)Hospital Universitario DonostiaServicio de Neurología, Hospital Arnau de VilanovaHospital Ruber InternacionalNeurology Department and Neurodegenerative Diseases Research GroupHospital Lucus AugustiHospital Rey Juan CarlosCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED)Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED)Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant PauAbstract Background Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.https://doi.org/10.1186/s12883-021-02485-1Parkinson’s diseasePD-MCICognitionLifestyleCoppadis |
| spellingShingle | Saul Martínez-Horta Helena Bejr-Kasem Andrea Horta-Barba Berta Pascual-Sedano Diego Santos-García Teresa de Deus-Fonticoba Silvia Jesús Miquel Aguilar Lluis Planellas Juan García-Caldentey Nuria Caballol Bárbara Vives-Pastor Jorge Hernández-Vara Iria Cabo-Lopez Lydia López-Manzanares Isabel González-Aramburu Maria Asunción Ávila-Rivera Maria Jose Catalán Luis Manuel López-Díaz Victor Puente Jose Manuel García-Moreno Carmen Borrué Berta Solano-Vila Maria Álvarez-Sauco Lydia Vela Sonia Escalante Esther Cubo Francisco Carrillo-Padilla Juan Carlos Martínez-Castrillo Pilar Sánchez-Alonso Maria Gema Alonso-Losada Nuria López-Ariztegui Itziar Gastón Marta Blázquez-Estrada Manual Seijo-Martínez Javier Rúiz-Martínez Caridad Valero-Merino Monica Kurtis Oriol de Fábregues-Boixar Jessica González-Ardura Cristina Prieto-Jurczynska Pablo Martinez-Martin Pablo Mir Jaime Kulisevsky COPPADIS Study Group Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease BMC Neurology Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis |
| title | Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease |
| title_full | Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease |
| title_fullStr | Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease |
| title_full_unstemmed | Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease |
| title_short | Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease |
| title_sort | identifying comorbidities and lifestyle factors contributing to the cognitive profile of early parkinson s disease |
| topic | Parkinson’s disease PD-MCI Cognition Lifestyle Coppadis |
| url | https://doi.org/10.1186/s12883-021-02485-1 |
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