Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study
Abstract Background Coronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze the clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. Methods From February 10th to April 15th, 2020, 103 COVID-19 patients...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-021-06495-9 |
| _version_ | 1818457129941467136 |
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| author | Yi Zhou Qiao Yang Jun Ye Xiaocheng Wu Xianhua Hou Yimei Feng Bangyu Luo Jixi Li Guangrong Yang Lingchen Li Xiu Yang Bin Wang Songtao Zhao Li Li Qi Li Zhi Xu Hao Wu Jianguo Sun |
| author_facet | Yi Zhou Qiao Yang Jun Ye Xiaocheng Wu Xianhua Hou Yimei Feng Bangyu Luo Jixi Li Guangrong Yang Lingchen Li Xiu Yang Bin Wang Songtao Zhao Li Li Qi Li Zhi Xu Hao Wu Jianguo Sun |
| author_sort | Yi Zhou |
| collection | DOAJ |
| description | Abstract Background Coronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze the clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. Methods From February 10th to April 15th, 2020, 103 COVID-19 patients with cancer were enrolled. Difference analyses were performed between severe and non-severe patients. A propensity score matching (PSM) analysis was performed, including 103 COVID-19 patients with cancer and 206 matched non-cancer COVID-19 patients. Next, we identified death related risk factors and developed a nomogram for predicting the probability. Results In 103 COVID-19 patients with cancer, the main cancer categories were breast cancer, lung cancer and bladder cancer. Compared to non-severe patients, severe patients had a higher median age, and a higher proportion of smokers, diabetes, heart disease and dyspnea. In addition, most of the laboratory results between two groups were significantly different. PSM analysis found that the proportion of dyspnea was much higher in COVID-19 patients with cancer. The severity incidence in two groups were similar, while a much higher mortality was found in COVID-19 patients with cancer compared to that in COVID-19 patients without cancer (11.7% vs. 4.4%, P = 0.028). Furthermore, we found that neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) were related to death outcome. And a nomogram based on the factors was developed. Conclusion In COVID-19 patients with cancer, the clinical features and laboratory results between severe group and non-severe group were significantly different. NLR and CRP were the risk factors that could predict death outcome. |
| first_indexed | 2024-12-14T22:37:40Z |
| format | Article |
| id | doaj.art-0b9ea4f3d5984d98be52bd2d4121298e |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T22:37:40Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-0b9ea4f3d5984d98be52bd2d4121298e2022-12-21T22:45:04ZengBMCBMC Infectious Diseases1471-23342021-08-0121111010.1186/s12879-021-06495-9Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective studyYi Zhou0Qiao Yang1Jun Ye2Xiaocheng Wu3Xianhua Hou4Yimei Feng5Bangyu Luo6Jixi Li7Guangrong Yang8Lingchen Li9Xiu Yang10Bin Wang11Songtao Zhao12Li Li13Qi Li14Zhi Xu15Hao Wu16Jianguo Sun17Cancer Institute, Xinqiao Hospital, Army Medical UniversityDepartment of Ultrasound, The 941st Hospital of the PLA Joint Logistic Support ForceDepartment of Gastroenterology, Southwest Hospital, Army Medical UniversityDepartment of Emergency, Xinqiao Hospital, Army Medical UniversityDepartment of Neurology, Southwest Hospital, Army Medical UniversityDepartment of Hematology, Xinqiao Hospital, Army Medical UniversityCancer Institute, Xinqiao Hospital, Army Medical UniversityCancer Institute, Xinqiao Hospital, Army Medical UniversityCancer Institute, Xinqiao Hospital, Army Medical UniversityCancer Institute, Xinqiao Hospital, Army Medical UniversityCancer Institute, Xinqiao Hospital, Army Medical UniversityDepartment of Respiratory and Intensive Care, Xinqiao Hospital, Army Medical UniversityInstitute of Infectious Diseases, Southwest Hospital, Army Medical UniversityDepartment of Respiratory Medicine, Army Medical CenterDepartment of Respiratory and Intensive Care, Xinqiao Hospital, Army Medical UniversityDepartment of Respiratory and Intensive Care, Xinqiao Hospital, Army Medical UniversityXinqiao Hospital, Army Medical UniversityCancer Institute, Xinqiao Hospital, Army Medical UniversityAbstract Background Coronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze the clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. Methods From February 10th to April 15th, 2020, 103 COVID-19 patients with cancer were enrolled. Difference analyses were performed between severe and non-severe patients. A propensity score matching (PSM) analysis was performed, including 103 COVID-19 patients with cancer and 206 matched non-cancer COVID-19 patients. Next, we identified death related risk factors and developed a nomogram for predicting the probability. Results In 103 COVID-19 patients with cancer, the main cancer categories were breast cancer, lung cancer and bladder cancer. Compared to non-severe patients, severe patients had a higher median age, and a higher proportion of smokers, diabetes, heart disease and dyspnea. In addition, most of the laboratory results between two groups were significantly different. PSM analysis found that the proportion of dyspnea was much higher in COVID-19 patients with cancer. The severity incidence in two groups were similar, while a much higher mortality was found in COVID-19 patients with cancer compared to that in COVID-19 patients without cancer (11.7% vs. 4.4%, P = 0.028). Furthermore, we found that neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) were related to death outcome. And a nomogram based on the factors was developed. Conclusion In COVID-19 patients with cancer, the clinical features and laboratory results between severe group and non-severe group were significantly different. NLR and CRP were the risk factors that could predict death outcome.https://doi.org/10.1186/s12879-021-06495-9COVID-19CancerNomogramNeutrophil-to-lymphocyte ratioC-reactive protein |
| spellingShingle | Yi Zhou Qiao Yang Jun Ye Xiaocheng Wu Xianhua Hou Yimei Feng Bangyu Luo Jixi Li Guangrong Yang Lingchen Li Xiu Yang Bin Wang Songtao Zhao Li Li Qi Li Zhi Xu Hao Wu Jianguo Sun Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study BMC Infectious Diseases COVID-19 Cancer Nomogram Neutrophil-to-lymphocyte ratio C-reactive protein |
| title | Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study |
| title_full | Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study |
| title_fullStr | Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study |
| title_full_unstemmed | Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study |
| title_short | Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study |
| title_sort | clinical features and death risk factors in covid 19 patients with cancer a retrospective study |
| topic | COVID-19 Cancer Nomogram Neutrophil-to-lymphocyte ratio C-reactive protein |
| url | https://doi.org/10.1186/s12879-021-06495-9 |
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