Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation
Abstract Cancers of the lymphatic system are broadly classified into Hodgkin and non‐Hodgkin types. Although lymphomas can be effectively treated with chemotherapy, this approach is associated with the risk of adverse side effects. High intake of certain vegetables and fruits is associated with a re...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.1228 |
| _version_ | 1797221326977499136 |
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| author | Huda Mohammed Al‐Shaya Haiwen Li Obaid U. Beg Anwar A. Hamama Sarah Melissa Witiak Paul Kaseloo Rafat A. Siddiqui |
| author_facet | Huda Mohammed Al‐Shaya Haiwen Li Obaid U. Beg Anwar A. Hamama Sarah Melissa Witiak Paul Kaseloo Rafat A. Siddiqui |
| author_sort | Huda Mohammed Al‐Shaya |
| collection | DOAJ |
| description | Abstract Cancers of the lymphatic system are broadly classified into Hodgkin and non‐Hodgkin types. Although lymphomas can be effectively treated with chemotherapy, this approach is associated with the risk of adverse side effects. High intake of certain vegetables and fruits is associated with a reduced risk of cancer development. We hypothesized that Annona fruit, which is rich in fibers and phytochemicals that are known to possess anticancer properties, can be effective in inhibiting lymphoma growth. The Annona fruit's fractions were extracted with water, methanol, or chloroform and then assayed for total phenolic, flavonoids, and tannins content; antioxidation activities; and inhibition of in vitro cell proliferation using the Ramos‐1 lymphoma cells. The methanol fractions contained the highest phenolics, flavonoids, and tannins content, and antioxidation activity. However, the methanol extracts of skin, pulp, and seeds had a moderate whereas the chloroform extracts of pulp and seeds had strong effects on Ramos‐1 cell proliferation. Our findings suggest that Annona fruits may be effective in the prevention or treatment of lymphoma. |
| first_indexed | 2024-04-24T13:03:40Z |
| format | Article |
| id | doaj.art-0b9f8234ad4d46fd94aae3593ef111d0 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-04-24T13:03:40Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-0b9f8234ad4d46fd94aae3593ef111d02024-04-05T09:16:02ZengWileyFood Science & Nutrition2048-71772020-01-0181586810.1002/fsn3.1228Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferationHuda Mohammed Al‐Shaya0Haiwen Li1Obaid U. Beg2Anwar A. Hamama3Sarah Melissa Witiak4Paul Kaseloo5Rafat A. Siddiqui6Food Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg VirginiaFood Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg VirginiaFood Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg VirginiaCommon Research Laboratory Agricultural Research Station College of Agriculture Virginia State University Petersburg VirginiaDepartment of Biology College of Natural and Health Sciences Virginia State University Petersburg VirginiaDepartment of Biology College of Natural and Health Sciences Virginia State University Petersburg VirginiaFood Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg VirginiaAbstract Cancers of the lymphatic system are broadly classified into Hodgkin and non‐Hodgkin types. Although lymphomas can be effectively treated with chemotherapy, this approach is associated with the risk of adverse side effects. High intake of certain vegetables and fruits is associated with a reduced risk of cancer development. We hypothesized that Annona fruit, which is rich in fibers and phytochemicals that are known to possess anticancer properties, can be effective in inhibiting lymphoma growth. The Annona fruit's fractions were extracted with water, methanol, or chloroform and then assayed for total phenolic, flavonoids, and tannins content; antioxidation activities; and inhibition of in vitro cell proliferation using the Ramos‐1 lymphoma cells. The methanol fractions contained the highest phenolics, flavonoids, and tannins content, and antioxidation activity. However, the methanol extracts of skin, pulp, and seeds had a moderate whereas the chloroform extracts of pulp and seeds had strong effects on Ramos‐1 cell proliferation. Our findings suggest that Annona fruits may be effective in the prevention or treatment of lymphoma.https://doi.org/10.1002/fsn3.1228anticancerantioxidantslymphomapolyphenolsramos‐1 cells |
| spellingShingle | Huda Mohammed Al‐Shaya Haiwen Li Obaid U. Beg Anwar A. Hamama Sarah Melissa Witiak Paul Kaseloo Rafat A. Siddiqui Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation Food Science & Nutrition anticancer antioxidants lymphoma polyphenols ramos‐1 cells |
| title | Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation |
| title_full | Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation |
| title_fullStr | Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation |
| title_full_unstemmed | Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation |
| title_short | Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation |
| title_sort | phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation |
| topic | anticancer antioxidants lymphoma polyphenols ramos‐1 cells |
| url | https://doi.org/10.1002/fsn3.1228 |
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