Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs
Multidrug transporters are membrane proteins that catalyze efflux of antibiotics and other toxic compounds from cells, thereby conferring drug resistance on various organisms. Unlike most solute transporters that transport a single type of compound or similar analogues, multidrug transporters are ex...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2014-09-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/divide-and-conquer-processive-transport-enables-multidrug-transporters-to-tackle-challenging-drugs/ |
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| author | Nir Fluman Eitan Bibi |
| author_facet | Nir Fluman Eitan Bibi |
| author_sort | Nir Fluman |
| collection | DOAJ |
| description | Multidrug transporters are membrane proteins that catalyze efflux of antibiotics and other toxic compounds from cells, thereby conferring drug resistance on various organisms. Unlike most solute transporters that transport a single type of compound or similar analogues, multidrug transporters are extremely promiscuous. They transport a broad spectrum of dissimilar drugs and represent a serious obstacle to antimicrobial or anticancer chemotherapy. Many challenging aspects of multidrug transporters, which are unique, have been studied in detail, including their ability to interact with chemically unrelated drugs, and how they utilize energy to drive efflux of compounds that are not only structurally but electrically different. A new and surprising dimension of the promiscuous nature of multidrug transporters has been described recently: they can move long molecules through the membrane in a processive manner. |
| first_indexed | 2024-12-20T02:15:46Z |
| format | Article |
| id | doaj.art-0ba06290142f4db4a8a397553139c582 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-12-20T02:15:46Z |
| publishDate | 2014-09-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-0ba06290142f4db4a8a397553139c5822022-12-21T19:56:56ZengShared Science Publishers OGMicrobial Cell2311-26382014-09-0111034935110.15698/mic2014.10.172Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugsNir Fluman0Eitan Bibi1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel 76100.Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel 76100.Multidrug transporters are membrane proteins that catalyze efflux of antibiotics and other toxic compounds from cells, thereby conferring drug resistance on various organisms. Unlike most solute transporters that transport a single type of compound or similar analogues, multidrug transporters are extremely promiscuous. They transport a broad spectrum of dissimilar drugs and represent a serious obstacle to antimicrobial or anticancer chemotherapy. Many challenging aspects of multidrug transporters, which are unique, have been studied in detail, including their ability to interact with chemically unrelated drugs, and how they utilize energy to drive efflux of compounds that are not only structurally but electrically different. A new and surprising dimension of the promiscuous nature of multidrug transporters has been described recently: they can move long molecules through the membrane in a processive manner.http://microbialcell.com/researcharticles/divide-and-conquer-processive-transport-enables-multidrug-transporters-to-tackle-challenging-drugs/multidrug resistancemultidrug transportMdfAdequaliniumantibioticssecondary transportdrug-proton exchange |
| spellingShingle | Nir Fluman Eitan Bibi Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs Microbial Cell multidrug resistance multidrug transport MdfA dequalinium antibiotics secondary transport drug-proton exchange |
| title | Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs |
| title_full | Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs |
| title_fullStr | Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs |
| title_full_unstemmed | Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs |
| title_short | Divide and conquer: processive transport enables multidrug transporters to tackle challenging drugs |
| title_sort | divide and conquer processive transport enables multidrug transporters to tackle challenging drugs |
| topic | multidrug resistance multidrug transport MdfA dequalinium antibiotics secondary transport drug-proton exchange |
| url | http://microbialcell.com/researcharticles/divide-and-conquer-processive-transport-enables-multidrug-transporters-to-tackle-challenging-drugs/ |
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