The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies
Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Soelaiman Ima-NirwanaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Bandar...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-10-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-osteoprotective-effects-of-kaempferol-the-evidence-from-in-vivo-an-peer-reviewed-article-DDDT |
| _version_ | 1818535772408512512 |
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| author | Wong SK Chin KY Ima-Nirwana S |
| author_facet | Wong SK Chin KY Ima-Nirwana S |
| author_sort | Wong SK |
| collection | DOAJ |
| description | Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Soelaiman Ima-NirwanaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaTel +60 3 9145 9579Fax +60 3 9145 9547Email imasoel@ppukm.ukm.edu.myAbstract: Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementation showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.Keywords: bone, flavonoid, fracture, osteoblast, osteoclast, osteoporosis |
| first_indexed | 2024-12-11T18:29:22Z |
| format | Article |
| id | doaj.art-0ba161b07d6447e7b7830023d8c8980e |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-11T18:29:22Z |
| publishDate | 2019-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-0ba161b07d6447e7b7830023d8c8980e2022-12-22T00:54:58ZengDove Medical PressDrug Design, Development and Therapy1177-88812019-10-01Volume 133497351448984The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro StudiesWong SKChin KYIma-Nirwana SSok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Soelaiman Ima-NirwanaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaTel +60 3 9145 9579Fax +60 3 9145 9547Email imasoel@ppukm.ukm.edu.myAbstract: Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementation showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.Keywords: bone, flavonoid, fracture, osteoblast, osteoclast, osteoporosishttps://www.dovepress.com/the-osteoprotective-effects-of-kaempferol-the-evidence-from-in-vivo-an-peer-reviewed-article-DDDTboneflavonoidfractureosteoblastosteoclastosteoporosis |
| spellingShingle | Wong SK Chin KY Ima-Nirwana S The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies Drug Design, Development and Therapy bone flavonoid fracture osteoblast osteoclast osteoporosis |
| title | The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies |
| title_full | The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies |
| title_fullStr | The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies |
| title_full_unstemmed | The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies |
| title_short | The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies |
| title_sort | osteoprotective effects of kaempferol the evidence from in vivo and in vitro studies |
| topic | bone flavonoid fracture osteoblast osteoclast osteoporosis |
| url | https://www.dovepress.com/the-osteoprotective-effects-of-kaempferol-the-evidence-from-in-vivo-an-peer-reviewed-article-DDDT |
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