Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro

Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro

Background: One of the therapeutic limitations of the use of doxorubicin (DOX) as an anticancer drug is its cardiotoxicity. Its hydrophilicity also causes difficulties in achieving sustained release. The simultaneous delivery with the well-known natural antioxidant quercetin could ameliorate its car...

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Bibliographic Details
Main Authors: Christina Voycheva, Teodora Popova, Marta Slavkova, Virginia Tzankova, Denitsa Stefanova, Diana Tzankova, Ivanka Spassova, Daniela Kovacheva, Borislav Tzankov
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Bioengineering
Subjects:
MCM-41 nanoparticles
carboxylic functionalization
doxorubicin
quercetin
cardiotoxicity
double loading
Online Access:https://www.mdpi.com/2306-5354/10/6/637

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