Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants
Background and aim: Hepatocellular carcinoma (HCC) is a significant complication of hepatitis B and still poses a global public health concern. This systematic review and meta-analysis provide adequate details on the prevalence of HCC in the HBV population within Southeast Asian countries. Method: F...
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2023-10-01
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| author | Ali A. Rabaan Kizito Eneye Bello Ahmad Adebayo Irekeola Nawal A. Al Kaabi Muhammad A. Halwani Amjad A. Yousuf Amer Alshengeti Amal H. Alfaraj Faryal Khamis Maha F. Al-Subaie Bashayer M. AlShehail Souad A. Almuthree Noha Y. Ibraheem Mahassen H. Khalifa Mubarak Alfaresi Mona A. Al Fares Mohammed Garout Ahmed Alsayyah Ahmad A. Alshehri Ali S. Alqahtani Mohammed Alissa |
| author_facet | Ali A. Rabaan Kizito Eneye Bello Ahmad Adebayo Irekeola Nawal A. Al Kaabi Muhammad A. Halwani Amjad A. Yousuf Amer Alshengeti Amal H. Alfaraj Faryal Khamis Maha F. Al-Subaie Bashayer M. AlShehail Souad A. Almuthree Noha Y. Ibraheem Mahassen H. Khalifa Mubarak Alfaresi Mona A. Al Fares Mohammed Garout Ahmed Alsayyah Ahmad A. Alshehri Ali S. Alqahtani Mohammed Alissa |
| author_sort | Ali A. Rabaan |
| collection | DOAJ |
| description | Background and aim: Hepatocellular carcinoma (HCC) is a significant complication of hepatitis B and still poses a global public health concern. This systematic review and meta-analysis provide adequate details on the prevalence of HCC in the HBV population within Southeast Asian countries. Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria, a thorough search for literature discussing the prevalence of HCC in the HBV population within southeast Asia was performed. Eligible studies were subjected to a meta-analysis utilising a DerSimonian and Laird approach and a random effect model. A protocol was registered with PROSPERO (CRD42023423953). Result: Our study meticulously recovered 41 articles from seven countries in Southeast Asia, namely Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. A total of 39,050 HBV patients and 7479 HCC cases in southeast Asia were analysed. The pooled prevalence of HCC in HBV cases within southeast Asia was 45.8% (95% CI, 34.3–57.8%, <i>I</i><sup>2</sup> = 99.51%, <i>p</i> < 0.001). Singapore (62.5%, CI: 42.4–79.1) had the highest pooled prevalence of HCC in the HBV population compared to Vietnam, with the lowest estimate (22.4%, CI: 9.9–44.9). There was a drop in the pooled prevalence of HCC in HBV from 2016 until now (37.6%, CI: 19.2–60.5). Conclusion: The findings of this review reveal a high pooled prevalence of HCC in the HBV population and therefore stir the need for routine screening, management, and surveillance. |
| first_indexed | 2024-03-10T20:59:16Z |
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| id | doaj.art-0ba3b427b1274306b423bf882101ac29 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T20:59:16Z |
| publishDate | 2023-10-01 |
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| series | Pathogens |
| spelling | doaj.art-0ba3b427b1274306b423bf882101ac292023-11-19T17:40:12ZengMDPI AGPathogens2076-08172023-10-011210122010.3390/pathogens12101220Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 ParticipantsAli A. Rabaan0Kizito Eneye Bello1Ahmad Adebayo Irekeola2Nawal A. Al Kaabi3Muhammad A. Halwani4Amjad A. Yousuf5Amer Alshengeti6Amal H. Alfaraj7Faryal Khamis8Maha F. Al-Subaie9Bashayer M. AlShehail10Souad A. Almuthree11Noha Y. Ibraheem12Mahassen H. Khalifa13Mubarak Alfaresi14Mona A. Al Fares15Mohammed Garout16Ahmed Alsayyah17Ahmad A. Alshehri18Ali S. Alqahtani19Mohammed Alissa20Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi ArabiaDepartment of Microbiology, Faculty of Natural Science, Kogi State University (Prince Abubakar Audu University) Anyigba, Anyigba PMB 1008, NigeriaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaCollege of Medicine and Health Science, Khalifa University, Abu Dhabi 127788, United Arab EmiratesDepartment of Medical Microbiology, Faculty of Medicine, Al Baha University, Al Baha 4781, Saudi ArabiaDepartment of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah 41411, Saudi ArabiaDepartment of Pediatrics, College of Medicine, Taibah University, Al-Madinah 41491, Saudi ArabiaPediatric Department, Abqaiq General Hospital, First Eastern Health Cluster, Abqaiq 33261, Saudi ArabiaInfection Diseases Unit, Department of Internal Medicine, Royal Hospital, Muscat 1331, OmanCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi ArabiaPharmacy Practice Department, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDepartment of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi ArabiaDepartment of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi ArabiaDepartment of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi ArabiaDepartment of Pathology and Laboratory Medicine, Zayed Military Hospital, Abu Dhabi 3740, United Arab EmiratesDepartment of Internal Medicine, King Abdulaziz University Hospital, Jeddah 21589, Saudi ArabiaDepartment of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi ArabiaDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Khalid University, Abha 61481, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaBackground and aim: Hepatocellular carcinoma (HCC) is a significant complication of hepatitis B and still poses a global public health concern. This systematic review and meta-analysis provide adequate details on the prevalence of HCC in the HBV population within Southeast Asian countries. Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria, a thorough search for literature discussing the prevalence of HCC in the HBV population within southeast Asia was performed. Eligible studies were subjected to a meta-analysis utilising a DerSimonian and Laird approach and a random effect model. A protocol was registered with PROSPERO (CRD42023423953). Result: Our study meticulously recovered 41 articles from seven countries in Southeast Asia, namely Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. A total of 39,050 HBV patients and 7479 HCC cases in southeast Asia were analysed. The pooled prevalence of HCC in HBV cases within southeast Asia was 45.8% (95% CI, 34.3–57.8%, <i>I</i><sup>2</sup> = 99.51%, <i>p</i> < 0.001). Singapore (62.5%, CI: 42.4–79.1) had the highest pooled prevalence of HCC in the HBV population compared to Vietnam, with the lowest estimate (22.4%, CI: 9.9–44.9). There was a drop in the pooled prevalence of HCC in HBV from 2016 until now (37.6%, CI: 19.2–60.5). Conclusion: The findings of this review reveal a high pooled prevalence of HCC in the HBV population and therefore stir the need for routine screening, management, and surveillance.https://www.mdpi.com/2076-0817/12/10/1220hepatocellular carcinomahepatitis B virusliver diseaseSoutheast Asiaprevalencesystematic review |
| spellingShingle | Ali A. Rabaan Kizito Eneye Bello Ahmad Adebayo Irekeola Nawal A. Al Kaabi Muhammad A. Halwani Amjad A. Yousuf Amer Alshengeti Amal H. Alfaraj Faryal Khamis Maha F. Al-Subaie Bashayer M. AlShehail Souad A. Almuthree Noha Y. Ibraheem Mahassen H. Khalifa Mubarak Alfaresi Mona A. Al Fares Mohammed Garout Ahmed Alsayyah Ahmad A. Alshehri Ali S. Alqahtani Mohammed Alissa Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants Pathogens hepatocellular carcinoma hepatitis B virus liver disease Southeast Asia prevalence systematic review |
| title | Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants |
| title_full | Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants |
| title_fullStr | Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants |
| title_full_unstemmed | Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants |
| title_short | Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants |
| title_sort | prevalence of hepatocellular carcinoma in hepatitis b population within southeast asia a systematic review and meta analysis of 39 050 participants |
| topic | hepatocellular carcinoma hepatitis B virus liver disease Southeast Asia prevalence systematic review |
| url | https://www.mdpi.com/2076-0817/12/10/1220 |
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