Strain-Specific Interactions between the Viral Capsid Proteins VP4, VP7 and VP6 Influence Rescue of Rotavirus Reassortants by Reverse Genetics

Strain-Specific Interactions between the Viral Capsid Proteins VP4, VP7 and VP6 Influence Rescue of Rotavirus Reassortants by Reverse Genetics

<i>Rotavirus A</i> (RVA) genome segments can reassort upon co-infection of target cells with two different RVA strains. However, not all reassortants are viable, which limits the ability to generate customized viruses for basic and applied research. To gain insight into the factors that...

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Bibliographic Details
Main Authors: Roman Valusenko-Mehrkens, Ashish K. Gadicherla, Reimar Johne, Alexander Falkenhagen
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
rotavirus
reassortment
VP4
VP7
VP6
reverse genetics system
Online Access:https://www.mdpi.com/1422-0067/24/6/5670

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