Honokiol Improves Liver Steatosis in Ovariectomized Mice
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, and is associated with the development of metabolic syndrome. Postmenopausal women with estrogen deficiency are at a higher risk of progression to NAFLD. Estrogen has a protective effect against the progression of the disease...
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MDPI AG
2018-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/1/194 |
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| author | Yeon-Hui Jeong Haeng Jeon Hur Eun-Joo Jeon Su-Jin Park Jin Taek Hwang Ae Sin Lee Kyong Won Lee Mi Jeong Sung |
| author_facet | Yeon-Hui Jeong Haeng Jeon Hur Eun-Joo Jeon Su-Jin Park Jin Taek Hwang Ae Sin Lee Kyong Won Lee Mi Jeong Sung |
| author_sort | Yeon-Hui Jeong |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, and is associated with the development of metabolic syndrome. Postmenopausal women with estrogen deficiency are at a higher risk of progression to NAFLD. Estrogen has a protective effect against the progression of the disease. Currently, there are no safe and effective treatments for these liver diseases in postmenopausal women. Honokiol (Ho), a bioactive natural product derived from Magnolia spp, has anti-inflammatory, anti-angiogenic, and anti-oxidative properties. In our study, we investigated the beneficial effects of Ho on NAFLD in ovariectomized (OVX) mice. We divided the mice into four groups, as follows: SHAM, OVX, OVX+β-estradiol (0.4 mg/kg of bodyweight), and OVX+Ho (50 mg/kg of diet). Mice were fed diets with/without Ho for 12 weeks. The bodyweight, epidermal fat, and weights of liver tissue were lower in the OVX group than in the other groups. Ho improved hepatic steatosis and reduced proinflammatory cytokine levels. Moreover, Ho markedly downregulated plasma lipid levels. Our results indicate that Ho ameliorated OVX-induced fatty liver and inflammation, as well as associated lipid metabolism. These findings suggest that Ho may be hepatoprotective against NAFLD in postmenopausal women. |
| first_indexed | 2024-04-12T21:14:36Z |
| format | Article |
| id | doaj.art-0ba5e0c03bc549ffb7c3cb573a184092 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T21:14:36Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0ba5e0c03bc549ffb7c3cb573a1840922022-12-22T03:16:29ZengMDPI AGMolecules1420-30492018-01-0123119410.3390/molecules23010194molecules23010194Honokiol Improves Liver Steatosis in Ovariectomized MiceYeon-Hui Jeong0Haeng Jeon Hur1Eun-Joo Jeon2Su-Jin Park3Jin Taek Hwang4Ae Sin Lee5Kyong Won Lee6Mi Jeong Sung7Division of Nutrition and Diet, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Nutrition and Diet, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Nutrition and Diet, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Nutrition and Diet, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Nutrition and Diet, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Functional Food Research, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Functional Food Research, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaDivision of Nutrition and Diet, Korea Food Research Institute, Jeollabuk-Do 55365, KoreaNonalcoholic fatty liver disease (NAFLD) is the most common liver disease, and is associated with the development of metabolic syndrome. Postmenopausal women with estrogen deficiency are at a higher risk of progression to NAFLD. Estrogen has a protective effect against the progression of the disease. Currently, there are no safe and effective treatments for these liver diseases in postmenopausal women. Honokiol (Ho), a bioactive natural product derived from Magnolia spp, has anti-inflammatory, anti-angiogenic, and anti-oxidative properties. In our study, we investigated the beneficial effects of Ho on NAFLD in ovariectomized (OVX) mice. We divided the mice into four groups, as follows: SHAM, OVX, OVX+β-estradiol (0.4 mg/kg of bodyweight), and OVX+Ho (50 mg/kg of diet). Mice were fed diets with/without Ho for 12 weeks. The bodyweight, epidermal fat, and weights of liver tissue were lower in the OVX group than in the other groups. Ho improved hepatic steatosis and reduced proinflammatory cytokine levels. Moreover, Ho markedly downregulated plasma lipid levels. Our results indicate that Ho ameliorated OVX-induced fatty liver and inflammation, as well as associated lipid metabolism. These findings suggest that Ho may be hepatoprotective against NAFLD in postmenopausal women.http://www.mdpi.com/1420-3049/23/1/194honokiolnonalcoholic fatty liver diseaseovariectomypostmenopausalliver steatosis |
| spellingShingle | Yeon-Hui Jeong Haeng Jeon Hur Eun-Joo Jeon Su-Jin Park Jin Taek Hwang Ae Sin Lee Kyong Won Lee Mi Jeong Sung Honokiol Improves Liver Steatosis in Ovariectomized Mice Molecules honokiol nonalcoholic fatty liver disease ovariectomy postmenopausal liver steatosis |
| title | Honokiol Improves Liver Steatosis in Ovariectomized Mice |
| title_full | Honokiol Improves Liver Steatosis in Ovariectomized Mice |
| title_fullStr | Honokiol Improves Liver Steatosis in Ovariectomized Mice |
| title_full_unstemmed | Honokiol Improves Liver Steatosis in Ovariectomized Mice |
| title_short | Honokiol Improves Liver Steatosis in Ovariectomized Mice |
| title_sort | honokiol improves liver steatosis in ovariectomized mice |
| topic | honokiol nonalcoholic fatty liver disease ovariectomy postmenopausal liver steatosis |
| url | http://www.mdpi.com/1420-3049/23/1/194 |
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