Blood levels of d-amino acids reflect the clinical course of COVID-19
d-Amino acids, rare enantiomers of amino acids, have been identified as biomarkers and therapeutic options for COVID-19. Methods for monitoring recovery are necessary for managing COVID-19. On the other hand, the presence of SARS-CoV2 virus in the blood is associated with worse outcomes. We investig...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240558082300033X |
| _version_ | 1827935571502170112 |
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| author | Shihoko Kimura-Ohba Yoshitsugu Takabatake Atsushi Takahashi Yoko Tanaka Shinsuke Sakai Yoshitaka Isaka Tomonori Kimura |
| author_facet | Shihoko Kimura-Ohba Yoshitsugu Takabatake Atsushi Takahashi Yoko Tanaka Shinsuke Sakai Yoshitaka Isaka Tomonori Kimura |
| author_sort | Shihoko Kimura-Ohba |
| collection | DOAJ |
| description | d-Amino acids, rare enantiomers of amino acids, have been identified as biomarkers and therapeutic options for COVID-19. Methods for monitoring recovery are necessary for managing COVID-19. On the other hand, the presence of SARS-CoV2 virus in the blood is associated with worse outcomes. We investigated the potential of d-amino acids for assessing recovery from severe COVID-19. In patients with severe COVID-19 requiring artificial ventilation, the blood levels of d-amino acids, including d-alanine, d-proline, d-serine, and d-asparagine, which were lower than the normal range before treatment, quickly and transiently increased and surpassed the upper limit of the normal range. This increase preceded the recovery of respiratory function, as indicated by ventilation weaning. The increase in blood d-amino acid levels was associated with the disappearance of the virus in the blood, but not with inflammatory manifestations or blood cytokine levels. d-Amino acids are sensitive biomarkers that reflect the recovery of the clinical course and blood viral load. Dynamic changes in blood d-amino acid levels are key indicators of clinical course. |
| first_indexed | 2024-03-13T07:56:44Z |
| format | Article |
| id | doaj.art-0ba63dadff05488ca7aea5032861f973 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-03-13T07:56:44Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-0ba63dadff05488ca7aea5032861f9732023-06-02T04:23:22ZengElsevierBiochemistry and Biophysics Reports2405-58082023-07-0134101452Blood levels of d-amino acids reflect the clinical course of COVID-19Shihoko Kimura-Ohba0Yoshitsugu Takabatake1Atsushi Takahashi2Yoko Tanaka3Shinsuke Sakai4Yoshitaka Isaka5Tomonori Kimura6Reverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan; KAGAMI Project, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, JapanDepartment of Nephrology, Osaka University Graduate School of Medicine, 565-0871, JapanDepartment of Nephrology, Osaka University Graduate School of Medicine, 565-0871, JapanReverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan; KAGAMI Project, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, JapanReverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan; KAGAMI Project, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan; Department of Nephrology, Osaka University Graduate School of Medicine, 565-0871, JapanDepartment of Nephrology, Osaka University Graduate School of Medicine, 565-0871, JapanReverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan; KAGAMI Project, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan; Department of Nephrology, Osaka University Graduate School of Medicine, 565-0871, Japan; Corresponding author. Reverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 567-0085, Japan.d-Amino acids, rare enantiomers of amino acids, have been identified as biomarkers and therapeutic options for COVID-19. Methods for monitoring recovery are necessary for managing COVID-19. On the other hand, the presence of SARS-CoV2 virus in the blood is associated with worse outcomes. We investigated the potential of d-amino acids for assessing recovery from severe COVID-19. In patients with severe COVID-19 requiring artificial ventilation, the blood levels of d-amino acids, including d-alanine, d-proline, d-serine, and d-asparagine, which were lower than the normal range before treatment, quickly and transiently increased and surpassed the upper limit of the normal range. This increase preceded the recovery of respiratory function, as indicated by ventilation weaning. The increase in blood d-amino acid levels was associated with the disappearance of the virus in the blood, but not with inflammatory manifestations or blood cytokine levels. d-Amino acids are sensitive biomarkers that reflect the recovery of the clinical course and blood viral load. Dynamic changes in blood d-amino acid levels are key indicators of clinical course.http://www.sciencedirect.com/science/article/pii/S240558082300033XCoronavirus disease 2019 (COVID-19)d-Amino acidBiomarkerSARS-CoV-2RecoveryTreatment |
| spellingShingle | Shihoko Kimura-Ohba Yoshitsugu Takabatake Atsushi Takahashi Yoko Tanaka Shinsuke Sakai Yoshitaka Isaka Tomonori Kimura Blood levels of d-amino acids reflect the clinical course of COVID-19 Biochemistry and Biophysics Reports Coronavirus disease 2019 (COVID-19) d-Amino acid Biomarker SARS-CoV-2 Recovery Treatment |
| title | Blood levels of d-amino acids reflect the clinical course of COVID-19 |
| title_full | Blood levels of d-amino acids reflect the clinical course of COVID-19 |
| title_fullStr | Blood levels of d-amino acids reflect the clinical course of COVID-19 |
| title_full_unstemmed | Blood levels of d-amino acids reflect the clinical course of COVID-19 |
| title_short | Blood levels of d-amino acids reflect the clinical course of COVID-19 |
| title_sort | blood levels of d amino acids reflect the clinical course of covid 19 |
| topic | Coronavirus disease 2019 (COVID-19) d-Amino acid Biomarker SARS-CoV-2 Recovery Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S240558082300033X |
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