Role of antiangiogenic agents in the treatment of metastatic colorectal cancer
This review covers the latest data on antiangiogenic agents used in patients with colorectal cancer. In this article, we describe drugs that have already been included into therapy regimens for colorectal cancer and vascular endothelial growth factor (VEGF) inhibitors that have been approved for oth...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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“ABV-press” Publishing house”, LLC
2018-05-01
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| Series: | Тазовая хирургия и онкология |
| Subjects: | |
| Online Access: | https://ok.abvpress.ru/jour/article/view/238 |
| _version_ | 1797705431628382208 |
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| author | M. V. Zabelin S. S. Gordeev L. O. Petrov A. A. Kostin S. E. Varlamova |
| author_facet | M. V. Zabelin S. S. Gordeev L. O. Petrov A. A. Kostin S. E. Varlamova |
| author_sort | M. V. Zabelin |
| collection | DOAJ |
| description | This review covers the latest data on antiangiogenic agents used in patients with colorectal cancer. In this article, we describe drugs that have already been included into therapy regimens for colorectal cancer and vascular endothelial growth factor (VEGF) inhibitors that have been approved for other indications. Targeted drugs with a similar mechanism of action that are currently in clinical trials are discussed separately. VEGF-inhibitors are one of the main groups of targeted drugs for colorectal cancer with an acceptable toxicity profile, which can be used both in combination with chemotherapeutic agents and as maintenance treatment. Moreover, these drugs are not dependent on mutational status, which is a significant advantage. |
| first_indexed | 2024-03-12T05:36:05Z |
| format | Article |
| id | doaj.art-0ba9be16c73040e2bbaad0cd0224040b |
| institution | Directory Open Access Journal |
| issn | 2686-9594 |
| language | Russian |
| last_indexed | 2024-03-12T05:36:05Z |
| publishDate | 2018-05-01 |
| publisher | “ABV-press” Publishing house”, LLC |
| record_format | Article |
| series | Тазовая хирургия и онкология |
| spelling | doaj.art-0ba9be16c73040e2bbaad0cd0224040b2023-09-03T06:24:42Zrus“ABV-press” Publishing house”, LLCТазовая хирургия и онкология2686-95942018-05-0181111810.17650/2220-3478-2018-8-1-11-18207Role of antiangiogenic agents in the treatment of metastatic colorectal cancerM. V. Zabelin0S. S. Gordeev1L. O. Petrov2A. A. Kostin3S. E. Varlamova4Federal Medical and Biological Agency of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaNational Medical Radiology Research Center, Ministry of Health of RussiaState Research Center – Burnasyan Federal Medical Biophysical Center, Federal Medical and Biological Agency of RussiaThis review covers the latest data on antiangiogenic agents used in patients with colorectal cancer. In this article, we describe drugs that have already been included into therapy regimens for colorectal cancer and vascular endothelial growth factor (VEGF) inhibitors that have been approved for other indications. Targeted drugs with a similar mechanism of action that are currently in clinical trials are discussed separately. VEGF-inhibitors are one of the main groups of targeted drugs for colorectal cancer with an acceptable toxicity profile, which can be used both in combination with chemotherapeutic agents and as maintenance treatment. Moreover, these drugs are not dependent on mutational status, which is a significant advantage.https://ok.abvpress.ru/jour/article/view/238colorectal cancerrectal cancertargeted therapyvegf inhibitors |
| spellingShingle | M. V. Zabelin S. S. Gordeev L. O. Petrov A. A. Kostin S. E. Varlamova Role of antiangiogenic agents in the treatment of metastatic colorectal cancer Тазовая хирургия и онкология colorectal cancer rectal cancer targeted therapy vegf inhibitors |
| title | Role of antiangiogenic agents in the treatment of metastatic colorectal cancer |
| title_full | Role of antiangiogenic agents in the treatment of metastatic colorectal cancer |
| title_fullStr | Role of antiangiogenic agents in the treatment of metastatic colorectal cancer |
| title_full_unstemmed | Role of antiangiogenic agents in the treatment of metastatic colorectal cancer |
| title_short | Role of antiangiogenic agents in the treatment of metastatic colorectal cancer |
| title_sort | role of antiangiogenic agents in the treatment of metastatic colorectal cancer |
| topic | colorectal cancer rectal cancer targeted therapy vegf inhibitors |
| url | https://ok.abvpress.ru/jour/article/view/238 |
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