The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility
Endometriosis is defined as a disorder in which the glands and stroma of the endometrium grow and shed periodically outside the uterine cavity. Highly prevalent in women of reproductive age, the most common clinical manifestations are chronic pelvic pain and infertility. The pathogenesis of endometr...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-08-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/28/8/10.31083/j.fbl2808166 |
| _version_ | 1827825217160871936 |
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| author | Qiongxiao Huang Yiqi Yu Weihai Xu Shishi Li Yier Zhou Jing Shu |
| author_facet | Qiongxiao Huang Yiqi Yu Weihai Xu Shishi Li Yier Zhou Jing Shu |
| author_sort | Qiongxiao Huang |
| collection | DOAJ |
| description | Endometriosis is defined as a disorder in which the glands and stroma of the endometrium grow and shed periodically outside the uterine cavity. Highly prevalent in women of reproductive age, the most common clinical manifestations are chronic pelvic pain and infertility. The pathogenesis of endometriosis may be multifactorial, including factors of anatomy, immunity, inflammation, hormones (estrogen), oxidative stress, genetics, epigenetics, and environment. There are generally three types of endometriotic disease, namely peritoneal, ovarian, and deep infiltration. For the same patient, there may be a single or multiple types concurrently. The different manifestations of these types suggests that they each have their own etiology. Numerous studies have shown that the evasion of endometrial cells from peritoneal immune surveillance helps establish and maintain peritoneal endometriosis, but the specific mechanism is not well understood. Likewise, the molecular mechanisms of endometriosis-related infertility have not been clearly elucidated. This review attempts to identify the role of peritoneal immunity in peritoneal endometriosis and related infertility, especially in the aspects of molecular mechanisms. |
| first_indexed | 2024-03-12T02:38:57Z |
| format | Article |
| id | doaj.art-0bac252a42d14a99814700f018697edd |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-12T02:38:57Z |
| publishDate | 2023-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-0bac252a42d14a99814700f018697edd2023-09-04T09:13:41ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-08-0128816610.31083/j.fbl2808166S2768-6701(23)00781-5The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related InfertilityQiongxiao Huang0Yiqi Yu1Weihai Xu2Shishi Li3Yier Zhou4Jing Shu5Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310016 Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310016 Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310016 Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310016 Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310016 Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, 310016 Hangzhou, Zhejiang, ChinaEndometriosis is defined as a disorder in which the glands and stroma of the endometrium grow and shed periodically outside the uterine cavity. Highly prevalent in women of reproductive age, the most common clinical manifestations are chronic pelvic pain and infertility. The pathogenesis of endometriosis may be multifactorial, including factors of anatomy, immunity, inflammation, hormones (estrogen), oxidative stress, genetics, epigenetics, and environment. There are generally three types of endometriotic disease, namely peritoneal, ovarian, and deep infiltration. For the same patient, there may be a single or multiple types concurrently. The different manifestations of these types suggests that they each have their own etiology. Numerous studies have shown that the evasion of endometrial cells from peritoneal immune surveillance helps establish and maintain peritoneal endometriosis, but the specific mechanism is not well understood. Likewise, the molecular mechanisms of endometriosis-related infertility have not been clearly elucidated. This review attempts to identify the role of peritoneal immunity in peritoneal endometriosis and related infertility, especially in the aspects of molecular mechanisms.https://www.imrpress.com/journal/FBL/28/8/10.31083/j.fbl2808166peritoneumimmuneendometriosislymphocytemacrophage |
| spellingShingle | Qiongxiao Huang Yiqi Yu Weihai Xu Shishi Li Yier Zhou Jing Shu The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility Frontiers in Bioscience-Landmark peritoneum immune endometriosis lymphocyte macrophage |
| title | The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility |
| title_full | The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility |
| title_fullStr | The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility |
| title_full_unstemmed | The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility |
| title_short | The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility |
| title_sort | role of peritoneal immunity in peritoneal endometriosis and related infertility |
| topic | peritoneum immune endometriosis lymphocyte macrophage |
| url | https://www.imrpress.com/journal/FBL/28/8/10.31083/j.fbl2808166 |
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