The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment
We studied oleogels containing zinc oxide nanoparticles (ZnO NPs) and lupane triterpenoids in sunflower oil for the treatment of burns. The modification of ZnO was carried out by treatment with alcohol solutions of betulin, betulonic acid, betulin diacetate and betulin diphosphate. The properties of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/9/207 |
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| author | Nina Melnikova Olga Vorobyova Alyona Balakireva Darina Malygina Anna Solovyeva Kseniya Belyaeva Dmitry Orekhov Alexander Knyazev |
| author_facet | Nina Melnikova Olga Vorobyova Alyona Balakireva Darina Malygina Anna Solovyeva Kseniya Belyaeva Dmitry Orekhov Alexander Knyazev |
| author_sort | Nina Melnikova |
| collection | DOAJ |
| description | We studied oleogels containing zinc oxide nanoparticles (ZnO NPs) and lupane triterpenoids in sunflower oil for the treatment of burns. The modification of ZnO was carried out by treatment with alcohol solutions of betulin, betulonic acid, betulin diacetate and betulin diphosphate. The properties of modified ZnO NPs were studied by powder XRD (average sizes of 10–20 nm), FTIR (νZnO 450 cm<sup>−1</sup>), UV–vis (345–360 nm), and blue–violet emission (380–420 nm). The identification and assay of modified ZnO NPs and triterpenoids were estimated. The treatment by oleogels of deep II-degree burns was studied on rats using histological studies, Doppler flowmetry and evaluation of enzymes activity and malonic dialdehyde (MDA) level. After the action of oleogels, burn wound area, and the necrosis decreased twice on the 10th day in comparison with the 1st day after burn. The microcirculation index in the near-wound zone by 20–30% improved compared with the group without treatment. Evaluation of the enzyme activity and the MDA level after treatment by oleogels during the course of 10 days showed them returning to normal. The improvement of antioxidant biochemical indexes, as well as wounds’ healing, was mainly determined by the influence of zinc oxide nanoparticles. |
| first_indexed | 2024-03-10T16:58:35Z |
| format | Article |
| id | doaj.art-0bade8f93b624837bd053315e1ce5e87 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T16:58:35Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0bade8f93b624837bd053315e1ce5e872023-11-20T11:02:27ZengMDPI AGPharmaceuticals1424-82472020-08-0113920710.3390/ph13090207The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn TreatmentNina Melnikova0Olga Vorobyova1Alyona Balakireva2Darina Malygina3Anna Solovyeva4Kseniya Belyaeva5Dmitry Orekhov6Alexander Knyazev7Department of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin sq., 603950 Nizhny Novgorod, RussiaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin sq., 603950 Nizhny Novgorod, RussiaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin sq., 603950 Nizhny Novgorod, RussiaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin sq., 603950 Nizhny Novgorod, RussiaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin sq., 603950 Nizhny Novgorod, RussiaDepartment of Pharmaceutical Chemistry, Privolzhsky Research Medical University, 10/1 Minin sq., 603950 Nizhny Novgorod, RussiaDepartment of Engineering Physics and Chemistry, Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin st., 603950 Nizhny Novgorod, RussiaFaculty of Chemistry, Lobachevsky University, 23/5 Gagarin Av., 603950 Nizhny Novgorod, RussiaWe studied oleogels containing zinc oxide nanoparticles (ZnO NPs) and lupane triterpenoids in sunflower oil for the treatment of burns. The modification of ZnO was carried out by treatment with alcohol solutions of betulin, betulonic acid, betulin diacetate and betulin diphosphate. The properties of modified ZnO NPs were studied by powder XRD (average sizes of 10–20 nm), FTIR (νZnO 450 cm<sup>−1</sup>), UV–vis (345–360 nm), and blue–violet emission (380–420 nm). The identification and assay of modified ZnO NPs and triterpenoids were estimated. The treatment by oleogels of deep II-degree burns was studied on rats using histological studies, Doppler flowmetry and evaluation of enzymes activity and malonic dialdehyde (MDA) level. After the action of oleogels, burn wound area, and the necrosis decreased twice on the 10th day in comparison with the 1st day after burn. The microcirculation index in the near-wound zone by 20–30% improved compared with the group without treatment. Evaluation of the enzyme activity and the MDA level after treatment by oleogels during the course of 10 days showed them returning to normal. The improvement of antioxidant biochemical indexes, as well as wounds’ healing, was mainly determined by the influence of zinc oxide nanoparticles.https://www.mdpi.com/1424-8247/13/9/207ZnO NPslupane triterpenoidsoleogelstreatment of burns |
| spellingShingle | Nina Melnikova Olga Vorobyova Alyona Balakireva Darina Malygina Anna Solovyeva Kseniya Belyaeva Dmitry Orekhov Alexander Knyazev The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment Pharmaceuticals ZnO NPs lupane triterpenoids oleogels treatment of burns |
| title | The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment |
| title_full | The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment |
| title_fullStr | The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment |
| title_full_unstemmed | The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment |
| title_short | The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment |
| title_sort | new pharmaceutical compositions of zinc oxide nanoparticles and triterpenoids for the burn treatment |
| topic | ZnO NPs lupane triterpenoids oleogels treatment of burns |
| url | https://www.mdpi.com/1424-8247/13/9/207 |
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