Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial
Fortification with multiple micronutrient powder has been proposed as a public health intervention able to reduce micronutrient deficiencies in children. Our objective was to compare the effectiveness of fortification with multiple micronutrient powder with drug supplementation in the prevention and...
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/7/2160 |
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| author | Malaine Morais Alves Machado Mirella de Paiva Lopes Raquel Machado Schincaglia Paulo Sérgio Sucasas da Costa Alexandre Siqueira Guedes Coelho Maria Claret Costa Monteiro Hadler |
| author_facet | Malaine Morais Alves Machado Mirella de Paiva Lopes Raquel Machado Schincaglia Paulo Sérgio Sucasas da Costa Alexandre Siqueira Guedes Coelho Maria Claret Costa Monteiro Hadler |
| author_sort | Malaine Morais Alves Machado |
| collection | DOAJ |
| description | Fortification with multiple micronutrient powder has been proposed as a public health intervention able to reduce micronutrient deficiencies in children. Our objective was to compare the effectiveness of fortification with multiple micronutrient powder with drug supplementation in the prevention and treatment of iron deficiency and anaemia. This was a cluster trial with anemic and non-anaemic children between six and 42 months old, in randomization data. Non anaemic children received fortification with multiple micronutrient powder or standard drug supplementation of ferrous sulfate associated with folic acid in a prevention dose. Anaemic children who were randomized to receive multiple micronutrient powder also received the recommended iron complementation for anaemia treatment. A total of 162 children were evaluated. The prevalence of anaemia decreased from 13.58 to 1.85%. Iron deficiency decreased from 21.74% to 7.89% (by serum ferritin) and iron deficiency decreased from 66.81 to 38.27% (by soluble transferrin receptor). No difference was identified between interventions for hemoglobin (<i>p</i> = 0.142), serum ferritin (<i>p</i> = 0.288), and soluble transferrin receptor (<i>p</i> = 0.156). Fortification with multiple micronutrient powder was effective in preventing iron deficiency and anaemia in children aged six to 48 months. In anaemic children; it was necessary to supplement the dose of multiple micronutrient powder with ferrous sulfate. |
| first_indexed | 2024-03-10T10:07:10Z |
| format | Article |
| id | doaj.art-0bb285aee7264a6fadaf748718716698 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:07:10Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0bb285aee7264a6fadaf7487187166982023-11-22T01:26:40ZengMDPI AGNutrients2072-66432021-06-01137216010.3390/nu13072160Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical TrialMalaine Morais Alves Machado0Mirella de Paiva Lopes1Raquel Machado Schincaglia2Paulo Sérgio Sucasas da Costa3Alexandre Siqueira Guedes Coelho4Maria Claret Costa Monteiro Hadler5Graduate Program in Health Sciences of the Federal University of Goiás, Faculty of Medicine, Federal University of Goiás, Goiânia 74605-050, Goiás, BrazilFaculty of Nutrition, Federal University of Goiás, Goiânia 74605-050, Goiás, BrazilResearch Laboratory in Clinical and Sports Nutrition, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-050, Goiás, BrazilDepartment of Pediatrics, School of Medicine, Federal University of Goiás, Goiânia 74605-050, Goiás, BrazilGraduate Program in Nutrition and Health of the Federal University of Goiás, Faculty of Nutrition Goiânia, Federal University of Goiás, Goiânia 74605-050, Goiás, BrazilGraduate Program in Health Sciences of the Federal University of Goiás, Faculty of Medicine, Federal University of Goiás, Goiânia 74605-050, Goiás, BrazilFortification with multiple micronutrient powder has been proposed as a public health intervention able to reduce micronutrient deficiencies in children. Our objective was to compare the effectiveness of fortification with multiple micronutrient powder with drug supplementation in the prevention and treatment of iron deficiency and anaemia. This was a cluster trial with anemic and non-anaemic children between six and 42 months old, in randomization data. Non anaemic children received fortification with multiple micronutrient powder or standard drug supplementation of ferrous sulfate associated with folic acid in a prevention dose. Anaemic children who were randomized to receive multiple micronutrient powder also received the recommended iron complementation for anaemia treatment. A total of 162 children were evaluated. The prevalence of anaemia decreased from 13.58 to 1.85%. Iron deficiency decreased from 21.74% to 7.89% (by serum ferritin) and iron deficiency decreased from 66.81 to 38.27% (by soluble transferrin receptor). No difference was identified between interventions for hemoglobin (<i>p</i> = 0.142), serum ferritin (<i>p</i> = 0.288), and soluble transferrin receptor (<i>p</i> = 0.156). Fortification with multiple micronutrient powder was effective in preventing iron deficiency and anaemia in children aged six to 48 months. In anaemic children; it was necessary to supplement the dose of multiple micronutrient powder with ferrous sulfate.https://www.mdpi.com/2072-6643/13/7/2160iron deficiencyanaemiamicronutrientsdeficiency diseaseschildren |
| spellingShingle | Malaine Morais Alves Machado Mirella de Paiva Lopes Raquel Machado Schincaglia Paulo Sérgio Sucasas da Costa Alexandre Siqueira Guedes Coelho Maria Claret Costa Monteiro Hadler Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial Nutrients iron deficiency anaemia micronutrients deficiency diseases children |
| title | Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial |
| title_full | Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial |
| title_fullStr | Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial |
| title_full_unstemmed | Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial |
| title_short | Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial |
| title_sort | effect of fortification with multiple micronutrient powder on the prevention and treatment of iron deficiency and anaemia in brazilian children a randomized clinical trial |
| topic | iron deficiency anaemia micronutrients deficiency diseases children |
| url | https://www.mdpi.com/2072-6643/13/7/2160 |
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