In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered
The binding of atenolol (selective β1-blocker) and amlodipine (calcium channel blocker) to bovine serum albumin (BSA) was studied by equilibrium dialysis method in order to have an insight into the binding chemistry of these two to BSA. Free atenolol concentration was increased due to addition of am...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2007-06-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | http://www.bdjpharmacol.com/journalbdps0201/020120.pdf |
| _version_ | 1818918062453161984 |
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| author | Md. Ashraful Alam, Md. Abdul Awal, Mahbub Mostofa, Md. Kamrul Islam and Nusrat Subhan |
| author_facet | Md. Ashraful Alam, Md. Abdul Awal, Mahbub Mostofa, Md. Kamrul Islam and Nusrat Subhan |
| author_sort | Md. Ashraful Alam, Md. Abdul Awal, Mahbub Mostofa, Md. Kamrul Islam and Nusrat Subhan |
| collection | DOAJ |
| description | The binding of atenolol (selective β1-blocker) and amlodipine (calcium channel blocker) to bovine serum albumin (BSA) was studied by equilibrium dialysis method in order to have an insight into the binding chemistry of these two to BSA. Free atenolol concentration was increased due to addition of amlodipine which reduced the binding of the compounds to BSA. However, the free fraction was increased to a level as it was expected from direct competitive displacement while the free atenolol concentration was increased according to increasing the amlodipine concentration when only the BSA was present. The result obtained when the binding site was blocked by sufficient amount of amlodipine was that the increment of free concentration of atenolol was prominent. When no amlodipine was added the free concentration of atenolol was only 28% whereas this release was 93 % to 98.01% when amlodipine was added with increasing concentration. |
| first_indexed | 2024-12-20T00:43:59Z |
| format | Article |
| id | doaj.art-0bb43ddf03b140d4a8c2f0bb1d70f136 |
| institution | Directory Open Access Journal |
| issn | 1991-007X 1991-0088 |
| language | English |
| last_indexed | 2024-12-20T00:43:59Z |
| publishDate | 2007-06-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-0bb43ddf03b140d4a8c2f0bb1d70f1362022-12-21T19:59:28ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882007-06-01212026In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administeredMd. Ashraful Alam, Md. Abdul Awal, Mahbub Mostofa, Md. Kamrul Islam and Nusrat SubhanThe binding of atenolol (selective β1-blocker) and amlodipine (calcium channel blocker) to bovine serum albumin (BSA) was studied by equilibrium dialysis method in order to have an insight into the binding chemistry of these two to BSA. Free atenolol concentration was increased due to addition of amlodipine which reduced the binding of the compounds to BSA. However, the free fraction was increased to a level as it was expected from direct competitive displacement while the free atenolol concentration was increased according to increasing the amlodipine concentration when only the BSA was present. The result obtained when the binding site was blocked by sufficient amount of amlodipine was that the increment of free concentration of atenolol was prominent. When no amlodipine was added the free concentration of atenolol was only 28% whereas this release was 93 % to 98.01% when amlodipine was added with increasing concentration.www.bdjpharmacol.com/journalbdps0201/020120.pdfequilibrium dialysisatenololamlodipineinteraction |
| spellingShingle | Md. Ashraful Alam, Md. Abdul Awal, Mahbub Mostofa, Md. Kamrul Islam and Nusrat Subhan In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered Bangladesh Journal of Pharmacology equilibrium dialysis atenolol amlodipine interaction |
| title | In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered |
| title_full | In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered |
| title_fullStr | In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered |
| title_full_unstemmed | In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered |
| title_short | In-vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co-administered |
| title_sort | in vitro displacement interaction of atenolol and amlodipine on binding with bovine serum albumin when co administered |
| topic | equilibrium dialysis atenolol amlodipine interaction |
| url | http://www.bdjpharmacol.com/journalbdps0201/020120.pdf |
| work_keys_str_mv | AT mdashrafulalammdabdulawalmahbubmostofamdkamrulislamandnusratsubhan invitrodisplacementinteractionofatenololandamlodipineonbindingwithbovineserumalbuminwhencoadministered |