Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP. Guanine nucleotide homeostasis is central to photoreceptor c...

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Bibliographic Details
Main Authors: Anna Plana-Bonamaisó, Santiago López-Begines, David Fernández-Justel, Alexandra Junza, Ariadna Soler-Tapia, Jordi Andilla, Pablo Loza-Alvarez, Jose Luis Rosa, Esther Miralles, Isidre Casals, Oscar Yanes, Pedro de la Villa, Ruben M Buey, Ana Méndez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
retinal dystrophy
photoreceptor metabolism
IMPDH1
enzymology
photoreceptor physiology
cGMP
Online Access:https://elifesciences.org/articles/56418

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