Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation
Transplantation in elderly patients is obviously more challenging due to existing underlying diseases, changes in pharmacokinetics of immunosuppressive drugs, polypragmasy, and transformation of immunoreactivity (immunosenescence). Our review presents data on modification of adaptive and innate immu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2021-09-01
|
| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/1254 |
| _version_ | 1826546271105581056 |
|---|---|
| author | V. A. Fedulkina A. V. Vatazin A. V. Kildyushevskiy A. B. Zulkarnayev D. V. Gubina M. P. Fedulkina |
| author_facet | V. A. Fedulkina A. V. Vatazin A. V. Kildyushevskiy A. B. Zulkarnayev D. V. Gubina M. P. Fedulkina |
| author_sort | V. A. Fedulkina |
| collection | DOAJ |
| description | Transplantation in elderly patients is obviously more challenging due to existing underlying diseases, changes in pharmacokinetics of immunosuppressive drugs, polypragmasy, and transformation of immunoreactivity (immunosenescence). Our review presents data on modification of adaptive and innate immunity during aging. It also considers the possibility of both reduced and adapted immunosuppressive therapy in elderly renal transplant recipients in achieving an optimal balance between efficacy and complications. |
| first_indexed | 2024-04-10T00:50:24Z |
| format | Article |
| id | doaj.art-0bb5b4e896364f6faf142739ab4b9373 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2025-03-14T05:31:06Z |
| publishDate | 2021-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj.art-0bb5b4e896364f6faf142739ab4b93732025-03-05T14:11:53ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912021-09-0123317117910.15825/1995-1191-2021-3-171-1791036Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantationV. A. Fedulkina0A. V. Vatazin1A. V. Kildyushevskiy2A. B. Zulkarnayev3D. V. Gubina4M. P. Fedulkina5Vladimirsky Moscow Regional Research Clinical InstituteVladimirsky Moscow Regional Research Clinical InstituteVladimirsky Moscow Regional Research Clinical InstituteVladimirsky Moscow Regional Research Clinical InstituteVladimirsky Moscow Regional Research Clinical InstituteVladimirsky Moscow Regional Research Clinical InstituteTransplantation in elderly patients is obviously more challenging due to existing underlying diseases, changes in pharmacokinetics of immunosuppressive drugs, polypragmasy, and transformation of immunoreactivity (immunosenescence). Our review presents data on modification of adaptive and innate immunity during aging. It also considers the possibility of both reduced and adapted immunosuppressive therapy in elderly renal transplant recipients in achieving an optimal balance between efficacy and complications.https://journal.transpl.ru/vtio/article/view/1254kidney transplantationagingimmunosenescenceimmunosuppressive therapy |
| spellingShingle | V. A. Fedulkina A. V. Vatazin A. V. Kildyushevskiy A. B. Zulkarnayev D. V. Gubina M. P. Fedulkina Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation Вестник трансплантологии и искусственных органов kidney transplantation aging immunosenescence immunosuppressive therapy |
| title | Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation |
| title_full | Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation |
| title_fullStr | Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation |
| title_full_unstemmed | Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation |
| title_short | Immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation |
| title_sort | immunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation |
| topic | kidney transplantation aging immunosenescence immunosuppressive therapy |
| url | https://journal.transpl.ru/vtio/article/view/1254 |
| work_keys_str_mv | AT vafedulkina immunosenescenceasareasonofindividualizingimmunosuppressivetherapyinkidneytransplantation AT avvatazin immunosenescenceasareasonofindividualizingimmunosuppressivetherapyinkidneytransplantation AT avkildyushevskiy immunosenescenceasareasonofindividualizingimmunosuppressivetherapyinkidneytransplantation AT abzulkarnayev immunosenescenceasareasonofindividualizingimmunosuppressivetherapyinkidneytransplantation AT dvgubina immunosenescenceasareasonofindividualizingimmunosuppressivetherapyinkidneytransplantation AT mpfedulkina immunosenescenceasareasonofindividualizingimmunosuppressivetherapyinkidneytransplantation |