Promotion of fracture healing by conjugated linoleic acid in rats
Background: The ability of fracture healing in Tibetans is significantly superior to Chinese Hans, which may attribute to factors from diet, altitude to physical conditions. Conjugated linoleic acid (CLA) is an important ingredient in Tibetan diet, playing a role in antioxidation, antiatherosclerosi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-07-01
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| Series: | Journal of Orthopaedic Surgery |
| Online Access: | https://doi.org/10.1177/2309499017718910 |
| _version_ | 1818063412476772352 |
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| author | Zhongshu Shan Zong-Ping Luo Xiaozhong Shen Liang Chen |
| author_facet | Zhongshu Shan Zong-Ping Luo Xiaozhong Shen Liang Chen |
| author_sort | Zhongshu Shan |
| collection | DOAJ |
| description | Background: The ability of fracture healing in Tibetans is significantly superior to Chinese Hans, which may attribute to factors from diet, altitude to physical conditions. Conjugated linoleic acid (CLA) is an important ingredient in Tibetan diet, playing a role in antioxidation, antiatherosclerosis, and decrease in body fat accumulation. Methods: This study further quantified CLA effect in fracture healing in rats using combined structural evaluation (X-ray and micro-computed tomography), biomechanical test, and histological examination. Results: CLA could promote fracture healing with quicker development of trabecular connection, network and thickening and were more active at the stage of bony union and remodeling. The load to failure could reach 78.12 ± 10.03 N, 41.4% stronger than the control by week 6 ( p = 0.0209). Conclusions: CLA improved the quality and mechanical strength of fracture healing in rats callus. The information may offer insight in development of new therapeutic strategies of fracture healing for general populations beyond Tibetans. |
| first_indexed | 2024-12-10T14:19:42Z |
| format | Article |
| id | doaj.art-0bb6d302da014876bdcf6ffd1cbcc806 |
| institution | Directory Open Access Journal |
| issn | 2309-4990 |
| language | English |
| last_indexed | 2024-12-10T14:19:42Z |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedic Surgery |
| spelling | doaj.art-0bb6d302da014876bdcf6ffd1cbcc8062022-12-22T01:45:13ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902017-07-012510.1177/2309499017718910Promotion of fracture healing by conjugated linoleic acid in ratsZhongshu Shan0Zong-Ping Luo1Xiaozhong Shen2Liang Chen3 Department of Orthopedic Surgery, People’s Hospital of Qinghai Province, Xining, Qinghai, People’s Republic of China Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China Department of Orthopedic Surgery, People’s Hospital of Qinghai Province, Xining, Qinghai, People’s Republic of China Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaBackground: The ability of fracture healing in Tibetans is significantly superior to Chinese Hans, which may attribute to factors from diet, altitude to physical conditions. Conjugated linoleic acid (CLA) is an important ingredient in Tibetan diet, playing a role in antioxidation, antiatherosclerosis, and decrease in body fat accumulation. Methods: This study further quantified CLA effect in fracture healing in rats using combined structural evaluation (X-ray and micro-computed tomography), biomechanical test, and histological examination. Results: CLA could promote fracture healing with quicker development of trabecular connection, network and thickening and were more active at the stage of bony union and remodeling. The load to failure could reach 78.12 ± 10.03 N, 41.4% stronger than the control by week 6 ( p = 0.0209). Conclusions: CLA improved the quality and mechanical strength of fracture healing in rats callus. The information may offer insight in development of new therapeutic strategies of fracture healing for general populations beyond Tibetans.https://doi.org/10.1177/2309499017718910 |
| spellingShingle | Zhongshu Shan Zong-Ping Luo Xiaozhong Shen Liang Chen Promotion of fracture healing by conjugated linoleic acid in rats Journal of Orthopaedic Surgery |
| title | Promotion of fracture healing by conjugated linoleic acid in rats |
| title_full | Promotion of fracture healing by conjugated linoleic acid in rats |
| title_fullStr | Promotion of fracture healing by conjugated linoleic acid in rats |
| title_full_unstemmed | Promotion of fracture healing by conjugated linoleic acid in rats |
| title_short | Promotion of fracture healing by conjugated linoleic acid in rats |
| title_sort | promotion of fracture healing by conjugated linoleic acid in rats |
| url | https://doi.org/10.1177/2309499017718910 |
| work_keys_str_mv | AT zhongshushan promotionoffracturehealingbyconjugatedlinoleicacidinrats AT zongpingluo promotionoffracturehealingbyconjugatedlinoleicacidinrats AT xiaozhongshen promotionoffracturehealingbyconjugatedlinoleicacidinrats AT liangchen promotionoffracturehealingbyconjugatedlinoleicacidinrats |