Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study
IntroductionFew studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors, and duration of 23 symptoms in a cohort of Mexic...
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Frontiers Media S.A.
2023-08-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1236702/full |
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| author | Isaac Núñez Isaac Núñez Joshua Gillard Joshua Gillard Joshua Gillard Joshua Gillard Sergio Fragoso-Saavedra Sergio Fragoso-Saavedra Sergio Fragoso-Saavedra Dorien Feyaerts León Islas-Weinstein Angel A. Gallegos-Guzmán Uriel Valente-García Justin Meyerowitz J. Daniel Kelly J. Daniel Kelly J. Daniel Kelly Han Chen Edward Ganio Alexander Benkendorff Jaime Flores-Gouyonnet Pedro Dammann-Beltrán José Francisco Heredia-González Gabriela A. Rangel-Gutiérrez Catherine A. Blish Catherine A. Blish Catherine A. Blish Catherine A. Blish Kari C. Nadeau Kari C. Nadeau Kari C. Nadeau Kari C. Nadeau Garry Nolan Jose C. Crispín Jose C. Crispín David R. McIlwain Brice Gaudillière Sergio I. Valdés-Ferrer Sergio I. Valdés-Ferrer |
| author_facet | Isaac Núñez Isaac Núñez Joshua Gillard Joshua Gillard Joshua Gillard Joshua Gillard Sergio Fragoso-Saavedra Sergio Fragoso-Saavedra Sergio Fragoso-Saavedra Dorien Feyaerts León Islas-Weinstein Angel A. Gallegos-Guzmán Uriel Valente-García Justin Meyerowitz J. Daniel Kelly J. Daniel Kelly J. Daniel Kelly Han Chen Edward Ganio Alexander Benkendorff Jaime Flores-Gouyonnet Pedro Dammann-Beltrán José Francisco Heredia-González Gabriela A. Rangel-Gutiérrez Catherine A. Blish Catherine A. Blish Catherine A. Blish Catherine A. Blish Kari C. Nadeau Kari C. Nadeau Kari C. Nadeau Kari C. Nadeau Garry Nolan Jose C. Crispín Jose C. Crispín David R. McIlwain Brice Gaudillière Sergio I. Valdés-Ferrer Sergio I. Valdés-Ferrer |
| author_sort | Isaac Núñez |
| collection | DOAJ |
| description | IntroductionFew studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors, and duration of 23 symptoms in a cohort of Mexican patients with PCC.MethodsWe prospectively enrolled and followed adult patients hospitalized for severe COVID-19 at a tertiary care centre in Mexico City. The incidence of PCC symptoms was determined using questionnaires. Unsupervised clustering of PCC symptom co-occurrence and Kaplan–Meier analyses of symptom persistence were performed. The effect of baseline clinical characteristics was evaluated using Cox regression models and reported with hazard ratios (HR).ResultsWe found that amongst 192 patients with PCC, respiratory problems were the most prevalent and commonly co-occurred with functional activity impairment. 56% had ≥5 persistent symptoms. Symptom persistence probability at 360 days 0.78. Prior SARS-CoV-2 vaccination and infection during the Delta variant wave were associated with a shorter duration of PCC. Male sex was associated with a shorter duration of functional activity impairment and respiratory symptoms. Hypertension and diabetes were associated with a longer duration of functional impairment. Previous vaccination accelerated PCC recovery.DiscussionIn our cohort, PCC symptoms were frequent (particularly respiratory and neurocognitive ones) and persistent. Importantly, prior SARS-CoV-2 vaccination resulted in a shorter duration of PCC. |
| first_indexed | 2024-03-12T11:22:39Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T11:22:39Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-0bb7fe6b72c541e9aab5fef4af1187ca2023-09-01T14:39:58ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-08-011010.3389/fmed.2023.12367021236702Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort studyIsaac Núñez0Isaac Núñez1Joshua Gillard2Joshua Gillard3Joshua Gillard4Joshua Gillard5Sergio Fragoso-Saavedra6Sergio Fragoso-Saavedra7Sergio Fragoso-Saavedra8Dorien Feyaerts9León Islas-Weinstein10Angel A. Gallegos-Guzmán11Uriel Valente-García12Justin Meyerowitz13J. Daniel Kelly14J. Daniel Kelly15J. Daniel Kelly16Han Chen17Edward Ganio18Alexander Benkendorff19Jaime Flores-Gouyonnet20Pedro Dammann-Beltrán21José Francisco Heredia-González22Gabriela A. Rangel-Gutiérrez23Catherine A. Blish24Catherine A. Blish25Catherine A. Blish26Catherine A. Blish27Kari C. Nadeau28Kari C. Nadeau29Kari C. Nadeau30Kari C. Nadeau31Garry Nolan32Jose C. Crispín33Jose C. Crispín34David R. McIlwain35Brice Gaudillière36Sergio I. Valdés-Ferrer37Sergio I. Valdés-Ferrer38Department of Medical Education, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDivision of Postrgraduate Studies, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, MexicoSection Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, NetherlandsRadboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, NetherlandsCenter for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, NetherlandsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Medical Education, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDivision of Postrgraduate Studies, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, MexicoCombined Study Plan in Medicine, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Neurology & Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Neurology & Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Neurology & Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States0Institute for Global Health Sciences, UCSF, San Francisco, CA, United States1F.IProctor Foundation, UCSF, San Francisco, CA, United States2Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States3Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Neurology & Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Neurology & Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoCombined Study Plan in Medicine, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, MexicoCombined Study Plan in Medicine, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico2Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, United States4Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States5Chan Zuckerberg Biohub, San Francisco, CA, United States6Division of Infectious Diseases, Stanford University, Stanford, CA, United States4Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States7Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, United States8Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, United States9Institute for Immunity, Transplantation, and Infectious Diseases, Stanford University, Stanford, CA, United States0Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States1School of Medicine and Health Sciencies, Tecnologico de Monterrey, Mexico City, Mexico2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico2Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Neurology & Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico3Center for Biomedical Science, Feinstein Institutes for Medical Research, New York, NY, United StatesIntroductionFew studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors, and duration of 23 symptoms in a cohort of Mexican patients with PCC.MethodsWe prospectively enrolled and followed adult patients hospitalized for severe COVID-19 at a tertiary care centre in Mexico City. The incidence of PCC symptoms was determined using questionnaires. Unsupervised clustering of PCC symptom co-occurrence and Kaplan–Meier analyses of symptom persistence were performed. The effect of baseline clinical characteristics was evaluated using Cox regression models and reported with hazard ratios (HR).ResultsWe found that amongst 192 patients with PCC, respiratory problems were the most prevalent and commonly co-occurred with functional activity impairment. 56% had ≥5 persistent symptoms. Symptom persistence probability at 360 days 0.78. Prior SARS-CoV-2 vaccination and infection during the Delta variant wave were associated with a shorter duration of PCC. Male sex was associated with a shorter duration of functional activity impairment and respiratory symptoms. Hypertension and diabetes were associated with a longer duration of functional impairment. Previous vaccination accelerated PCC recovery.DiscussionIn our cohort, PCC symptoms were frequent (particularly respiratory and neurocognitive ones) and persistent. Importantly, prior SARS-CoV-2 vaccination resulted in a shorter duration of PCC.https://www.frontiersin.org/articles/10.3389/fmed.2023.1236702/fullpost-COVID-19 conditionslong COVIDpersistent COVIDSARS-CoV-2Mexico |
| spellingShingle | Isaac Núñez Isaac Núñez Joshua Gillard Joshua Gillard Joshua Gillard Joshua Gillard Sergio Fragoso-Saavedra Sergio Fragoso-Saavedra Sergio Fragoso-Saavedra Dorien Feyaerts León Islas-Weinstein Angel A. Gallegos-Guzmán Uriel Valente-García Justin Meyerowitz J. Daniel Kelly J. Daniel Kelly J. Daniel Kelly Han Chen Edward Ganio Alexander Benkendorff Jaime Flores-Gouyonnet Pedro Dammann-Beltrán José Francisco Heredia-González Gabriela A. Rangel-Gutiérrez Catherine A. Blish Catherine A. Blish Catherine A. Blish Catherine A. Blish Kari C. Nadeau Kari C. Nadeau Kari C. Nadeau Kari C. Nadeau Garry Nolan Jose C. Crispín Jose C. Crispín David R. McIlwain Brice Gaudillière Sergio I. Valdés-Ferrer Sergio I. Valdés-Ferrer Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study Frontiers in Medicine post-COVID-19 conditions long COVID persistent COVID SARS-CoV-2 Mexico |
| title | Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study |
| title_full | Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study |
| title_fullStr | Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study |
| title_full_unstemmed | Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study |
| title_short | Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study |
| title_sort | longitudinal clinical phenotyping of post covid condition in mexican adults recovering from severe covid 19 a prospective cohort study |
| topic | post-COVID-19 conditions long COVID persistent COVID SARS-CoV-2 Mexico |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1236702/full |
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