Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies
In recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na<sup>+</sup>,K<sup>+</sup>-ATPase ligands, play an integral role in the physiological and pathophysiological processes in the body. However, little is known about the function of these com...
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/7/1820 |
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| author | Alisa A. Markina Rogneda B. Kazanskaya Julia A. Timoshina Vladislav A. Zavialov Denis A. Abaimov Anna B. Volnova Tatiana N. Fedorova Raul R. Gainetdinov Alexander V. Lopachev |
| author_facet | Alisa A. Markina Rogneda B. Kazanskaya Julia A. Timoshina Vladislav A. Zavialov Denis A. Abaimov Anna B. Volnova Tatiana N. Fedorova Raul R. Gainetdinov Alexander V. Lopachev |
| author_sort | Alisa A. Markina |
| collection | DOAJ |
| description | In recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na<sup>+</sup>,K<sup>+</sup>-ATPase ligands, play an integral role in the physiological and pathophysiological processes in the body. However, little is known about the function of these compounds in the central nervous system. Endogenous cardiotonic steroids are involved in the pathogenesis of affective disorders, including depression and bipolar disorder, which are linked to dopaminergic system dysfunction. Animal models have shown that the cardiotonic steroid ouabain induces mania-like behavior through dopamine-dependent intracellular signaling pathways. In addition, mutations in the alpha subunit of Na<sup>+</sup>,K<sup>+</sup>-ATPase lead to the development of neurological pathologies. Evidence from animal models confirms the neurological consequences of mutations in the Na<sup>+</sup>,K<sup>+</sup>-ATPase alpha subunit. This review is dedicated to discussing the role of cardiotonic steroids and Na<sup>+</sup>,K<sup>+</sup>-ATPase in dopaminergic system pathologies—both the evidence supporting their involvement and potential pathways along which they may exert their effects are evaluated. Since there is an association between affective disorders accompanied by functional alterations in the dopaminergic system and neurological disorders such as Parkinson’s disease, we extend our discussion to the role of Na<sup>+</sup>,K<sup>+</sup>-ATPase and cardiotonic steroids in neurodegenerative diseases as well. |
| first_indexed | 2024-03-11T01:16:17Z |
| format | Article |
| id | doaj.art-0bb9c854e3214153ba75b60d45fcea51 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:16:17Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0bb9c854e3214153ba75b60d45fcea512023-11-18T18:25:25ZengMDPI AGBiomedicines2227-90592023-06-01117182010.3390/biomedicines11071820Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System PathologiesAlisa A. Markina0Rogneda B. Kazanskaya1Julia A. Timoshina2Vladislav A. Zavialov3Denis A. Abaimov4Anna B. Volnova5Tatiana N. Fedorova6Raul R. Gainetdinov7Alexander V. Lopachev8Biological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 Saint Petersburg, RussiaBiological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 Saint Petersburg, RussiaResearch Center of Neurology, Volokolamskoye Ahosse 80, 125367 Moscow, RussiaBiological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 Saint Petersburg, RussiaResearch Center of Neurology, Volokolamskoye Ahosse 80, 125367 Moscow, RussiaBiological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 Saint Petersburg, RussiaResearch Center of Neurology, Volokolamskoye Ahosse 80, 125367 Moscow, RussiaInstitute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 Saint Petersburg, RussiaInstitute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 Saint Petersburg, RussiaIn recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na<sup>+</sup>,K<sup>+</sup>-ATPase ligands, play an integral role in the physiological and pathophysiological processes in the body. However, little is known about the function of these compounds in the central nervous system. Endogenous cardiotonic steroids are involved in the pathogenesis of affective disorders, including depression and bipolar disorder, which are linked to dopaminergic system dysfunction. Animal models have shown that the cardiotonic steroid ouabain induces mania-like behavior through dopamine-dependent intracellular signaling pathways. In addition, mutations in the alpha subunit of Na<sup>+</sup>,K<sup>+</sup>-ATPase lead to the development of neurological pathologies. Evidence from animal models confirms the neurological consequences of mutations in the Na<sup>+</sup>,K<sup>+</sup>-ATPase alpha subunit. This review is dedicated to discussing the role of cardiotonic steroids and Na<sup>+</sup>,K<sup>+</sup>-ATPase in dopaminergic system pathologies—both the evidence supporting their involvement and potential pathways along which they may exert their effects are evaluated. Since there is an association between affective disorders accompanied by functional alterations in the dopaminergic system and neurological disorders such as Parkinson’s disease, we extend our discussion to the role of Na<sup>+</sup>,K<sup>+</sup>-ATPase and cardiotonic steroids in neurodegenerative diseases as well.https://www.mdpi.com/2227-9059/11/7/1820Na<sup>+</sup>,K<sup>+</sup>-ATPasecardiotonic steroidsdopaminebipolar disorderdepressionneurodegeneration |
| spellingShingle | Alisa A. Markina Rogneda B. Kazanskaya Julia A. Timoshina Vladislav A. Zavialov Denis A. Abaimov Anna B. Volnova Tatiana N. Fedorova Raul R. Gainetdinov Alexander V. Lopachev Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies Biomedicines Na<sup>+</sup>,K<sup>+</sup>-ATPase cardiotonic steroids dopamine bipolar disorder depression neurodegeneration |
| title | Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies |
| title_full | Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies |
| title_fullStr | Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies |
| title_full_unstemmed | Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies |
| title_short | Na<sup>+</sup>,K<sup>+</sup>-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies |
| title_sort | na sup sup k sup sup atpase and cardiotonic steroids in models of dopaminergic system pathologies |
| topic | Na<sup>+</sup>,K<sup>+</sup>-ATPase cardiotonic steroids dopamine bipolar disorder depression neurodegeneration |
| url | https://www.mdpi.com/2227-9059/11/7/1820 |
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