Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy
Abstract Quantitative muscle MRI (water-T2 and fat mapping) is being increasingly used to assess disease involvement in muscle disorders, while imaging techniques for assessment of the dynamic and elastic muscle properties have not yet been translated into clinics. In this exploratory study, we quan...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11147-2 |
| _version_ | 1811305864769830912 |
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| author | Xeni Deligianni Francesco Santini Matteo Paoletti Francesca Solazzo Niels Bergsland Giovanni Savini Arianna Faggioli Giancarlo Germani Mauro Monforte Enzo Ricci Giorgio Tasca Anna Pichiecchio |
| author_facet | Xeni Deligianni Francesco Santini Matteo Paoletti Francesca Solazzo Niels Bergsland Giovanni Savini Arianna Faggioli Giancarlo Germani Mauro Monforte Enzo Ricci Giorgio Tasca Anna Pichiecchio |
| author_sort | Xeni Deligianni |
| collection | DOAJ |
| description | Abstract Quantitative muscle MRI (water-T2 and fat mapping) is being increasingly used to assess disease involvement in muscle disorders, while imaging techniques for assessment of the dynamic and elastic muscle properties have not yet been translated into clinics. In this exploratory study, we quantitatively characterized muscle deformation (strain) in patients affected by facioscapulohumeral muscular dystrophy (FSHD), a prevalent muscular dystrophy, by applying dynamic MRI synchronized with neuromuscular electrical stimulation (NMES). We evaluated the quadriceps muscles in 34 ambulatory patients and 13 healthy controls, at 6-to 12-month time intervals. While a subgroup of patients behaved similarly to controls, for another subgroup the median strain decreased over time (approximately 57% over 1.5 years). Dynamic MRI parameters did not correlate with quantitative MRI. Our results suggest that the evaluation of muscle contraction by NMES-MRI is feasible and could potentially be used to explore the elastic properties and monitor muscle involvement in FSHD and other neuromuscular disorders. |
| first_indexed | 2024-04-13T08:34:08Z |
| format | Article |
| id | doaj.art-0bba135abdb34bfcb4a315f855e32d9c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T08:34:08Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0bba135abdb34bfcb4a315f855e32d9c2022-12-22T02:54:10ZengNature PortfolioScientific Reports2045-23222022-05-0112111210.1038/s41598-022-11147-2Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophyXeni Deligianni0Francesco Santini1Matteo Paoletti2Francesca Solazzo3Niels Bergsland4Giovanni Savini5Arianna Faggioli6Giancarlo Germani7Mauro Monforte8Enzo Ricci9Giorgio Tasca10Anna Pichiecchio11Radiology, Division of Radiological Physics, University Hospital of BaselRadiology, Division of Radiological Physics, University Hospital of BaselNeuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino FoundationSchool of Specialization in Clinical Pharmacology and Toxicology Center of Research in Medical Pharmacology, School of Medicine, University of InsubriaDepartment of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical SciencesNeuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino FoundationNeuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino FoundationNeuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino FoundationUnità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCSUnità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCSUnità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCSNeuroradiology Department, Advanced Imaging and Radiomics Center, IRCCS Mondino FoundationAbstract Quantitative muscle MRI (water-T2 and fat mapping) is being increasingly used to assess disease involvement in muscle disorders, while imaging techniques for assessment of the dynamic and elastic muscle properties have not yet been translated into clinics. In this exploratory study, we quantitatively characterized muscle deformation (strain) in patients affected by facioscapulohumeral muscular dystrophy (FSHD), a prevalent muscular dystrophy, by applying dynamic MRI synchronized with neuromuscular electrical stimulation (NMES). We evaluated the quadriceps muscles in 34 ambulatory patients and 13 healthy controls, at 6-to 12-month time intervals. While a subgroup of patients behaved similarly to controls, for another subgroup the median strain decreased over time (approximately 57% over 1.5 years). Dynamic MRI parameters did not correlate with quantitative MRI. Our results suggest that the evaluation of muscle contraction by NMES-MRI is feasible and could potentially be used to explore the elastic properties and monitor muscle involvement in FSHD and other neuromuscular disorders.https://doi.org/10.1038/s41598-022-11147-2 |
| spellingShingle | Xeni Deligianni Francesco Santini Matteo Paoletti Francesca Solazzo Niels Bergsland Giovanni Savini Arianna Faggioli Giancarlo Germani Mauro Monforte Enzo Ricci Giorgio Tasca Anna Pichiecchio Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy Scientific Reports |
| title | Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy |
| title_full | Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy |
| title_fullStr | Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy |
| title_full_unstemmed | Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy |
| title_short | Dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy |
| title_sort | dynamic magnetic resonance imaging of muscle contraction in facioscapulohumeral muscular dystrophy |
| url | https://doi.org/10.1038/s41598-022-11147-2 |
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