An in vitro co-culture mouse model demonstrates efficient vaccine-mediated control of Francisella tularensis SCHU S4 and identifies nitric oxide as a predictor of efficacy

An in vitro co-culture mouse model demonstrates efficient vaccine-mediated control of Francisella tularensis SCHU S4 and identifies nitric oxide as a predictor of efficacy

Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a c...

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Bibliographic Details
Main Authors: Igor Golovlev, Helena Lindgren, Kjell Eneslätt, Wayne Conlan, Amandine Mosnier, Thomas Henry, Anders Sjöstedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Nitric Oxide
correlates of protection
F. tularensis SCHU S4
in vitro co-culture model
mouse immune response
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00152/full

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