A potential synbiotic product improves the lipid profile of diabetic rats
<p>Abstract</p> <p>Background</p> <p>Previous studies showed that intake of yacon or some lactic acid bacteria was able to inhibit the development of diabetes mellitus, by reducing glucose and associated symptoms, for example, the lipid profile.</p> <p>Objec...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/11/1/114 |
| _version_ | 1818021165316177920 |
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| author | Roselino Mariana N Pauly-Silveira Nadiége D Cavallini Daniela CU Celiberto Larissa S Pinto Roseli A Vendramini Regina C Rossi Elizeu A |
| author_facet | Roselino Mariana N Pauly-Silveira Nadiége D Cavallini Daniela CU Celiberto Larissa S Pinto Roseli A Vendramini Regina C Rossi Elizeu A |
| author_sort | Roselino Mariana N |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Previous studies showed that intake of yacon or some lactic acid bacteria was able to inhibit the development of diabetes mellitus, by reducing glucose and associated symptoms, for example, the lipid profile.</p> <p>Objective</p> <p>The purpose of this study was to assess the consumption influence of a potential symbiotic product of soybean and yacon extract and fermented <it>Enterococcus faecium</it> CRL 183 and <it>Lactobacillus helveticus</it> ssp <it>jugurti</it> 416 in reducing blood glucose and lipid levels in an animal model.</p> <p>Methods</p> <p>Diabetes mellitus was chemically induced by intraperitoneal administration of streptozotocin (50 mg/kg body weight). The rats were divided into four groups (n=10): GI – non-diabetic animals that received only a standard chow diet (negative control), GII – diabetic animals that received only chow diet (positive control), GIII – diabetic animals that received the chow diet + 1 mL/kg body weight/day of soybean and yacon unfermented product, GIV – diabetic rats that received the chow diet + 1 mL/kg body weight/day of soybean and yacon fermented product. There was a seven-week treatment period and the following parameters were evaluated: animal body weight, food and water intake, blood glucose, enzyme activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), triglycerides levels, total cholesterol, HDL-C, non-HDL-C. Cell viability of the fermented product was checked weekly for a seven-week period.</p> <p>Results</p> <p>The product average viable population was 10<sup>8</sup>-10<sup>9</sup> CFU/mL, by ensuring both the rods and cocci regular intake. No difference was observed between the water and feed intake and body weight of groups that received unfermented and fermented products and the untreated diabetic group. The same was observed for the blood glucose and AST and ALT activities, while some improvement was observed for a lipid profile, represented by reduction of triglycerides level by 15.07% and 33.50% in groups III and IV, respectively, and an increase of 23.70% in HDL-C level for group IV.</p> <p>Conclusion</p> <p>The results showed that the ingestion of a potential symbiotic product was neither able to promote improvement in some of the disease symptoms, nor reduce blood glucose. However, a positive effect on triglycerides levels and HDL-cholesterol was observed in the groups that received the unfermented product containing yacon extract and the fermented product with <it>Enterococcus faecium</it> CRL 183, as well as <it>Lactobacillus helveticus</it> ssp <it>jugurti</it> 416 and yacon extract (symbiotic product).</p> |
| first_indexed | 2024-04-14T08:15:13Z |
| format | Article |
| id | doaj.art-0bbe03de026d479bbf8a4ede14c581c6 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-14T08:15:13Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-0bbe03de026d479bbf8a4ede14c581c62022-12-22T02:04:26ZengBMCLipids in Health and Disease1476-511X2012-09-0111111410.1186/1476-511X-11-114A potential synbiotic product improves the lipid profile of diabetic ratsRoselino Mariana NPauly-Silveira Nadiége DCavallini Daniela CUCeliberto Larissa SPinto Roseli AVendramini Regina CRossi Elizeu A<p>Abstract</p> <p>Background</p> <p>Previous studies showed that intake of yacon or some lactic acid bacteria was able to inhibit the development of diabetes mellitus, by reducing glucose and associated symptoms, for example, the lipid profile.</p> <p>Objective</p> <p>The purpose of this study was to assess the consumption influence of a potential symbiotic product of soybean and yacon extract and fermented <it>Enterococcus faecium</it> CRL 183 and <it>Lactobacillus helveticus</it> ssp <it>jugurti</it> 416 in reducing blood glucose and lipid levels in an animal model.</p> <p>Methods</p> <p>Diabetes mellitus was chemically induced by intraperitoneal administration of streptozotocin (50 mg/kg body weight). The rats were divided into four groups (n=10): GI – non-diabetic animals that received only a standard chow diet (negative control), GII – diabetic animals that received only chow diet (positive control), GIII – diabetic animals that received the chow diet + 1 mL/kg body weight/day of soybean and yacon unfermented product, GIV – diabetic rats that received the chow diet + 1 mL/kg body weight/day of soybean and yacon fermented product. There was a seven-week treatment period and the following parameters were evaluated: animal body weight, food and water intake, blood glucose, enzyme activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), triglycerides levels, total cholesterol, HDL-C, non-HDL-C. Cell viability of the fermented product was checked weekly for a seven-week period.</p> <p>Results</p> <p>The product average viable population was 10<sup>8</sup>-10<sup>9</sup> CFU/mL, by ensuring both the rods and cocci regular intake. No difference was observed between the water and feed intake and body weight of groups that received unfermented and fermented products and the untreated diabetic group. The same was observed for the blood glucose and AST and ALT activities, while some improvement was observed for a lipid profile, represented by reduction of triglycerides level by 15.07% and 33.50% in groups III and IV, respectively, and an increase of 23.70% in HDL-C level for group IV.</p> <p>Conclusion</p> <p>The results showed that the ingestion of a potential symbiotic product was neither able to promote improvement in some of the disease symptoms, nor reduce blood glucose. However, a positive effect on triglycerides levels and HDL-cholesterol was observed in the groups that received the unfermented product containing yacon extract and the fermented product with <it>Enterococcus faecium</it> CRL 183, as well as <it>Lactobacillus helveticus</it> ssp <it>jugurti</it> 416 and yacon extract (symbiotic product).</p>http://www.lipidworld.com/content/11/1/114Fermented soy productProbioticsPrebioticsDiabetes mellitusBlood glucoseLipid profile |
| spellingShingle | Roselino Mariana N Pauly-Silveira Nadiége D Cavallini Daniela CU Celiberto Larissa S Pinto Roseli A Vendramini Regina C Rossi Elizeu A A potential synbiotic product improves the lipid profile of diabetic rats Lipids in Health and Disease Fermented soy product Probiotics Prebiotics Diabetes mellitus Blood glucose Lipid profile |
| title | A potential synbiotic product improves the lipid profile of diabetic rats |
| title_full | A potential synbiotic product improves the lipid profile of diabetic rats |
| title_fullStr | A potential synbiotic product improves the lipid profile of diabetic rats |
| title_full_unstemmed | A potential synbiotic product improves the lipid profile of diabetic rats |
| title_short | A potential synbiotic product improves the lipid profile of diabetic rats |
| title_sort | potential synbiotic product improves the lipid profile of diabetic rats |
| topic | Fermented soy product Probiotics Prebiotics Diabetes mellitus Blood glucose Lipid profile |
| url | http://www.lipidworld.com/content/11/1/114 |
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