Effect of sidestream cigarette smoking on memory of male Long-Evans rats

Background: Memory impairment is an important presentation of many diseases. Sidestream cigarette smoke (SCS), a form of passive smoke, causes neural complications such as impaired memory. The aim of this study was to assess the effect of sidestream cigarette smoke on memory of male Long-Evans rats...

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Main Authors: Amina Begum, Md. Shaiful Islam Patwary, Adity Ara Trisha, Shorifa Shahjadi
Format: Article
Language:English
Published: Bangabandhu Sheikh Mujib Medical University 2024-03-01
Series:Bangabandhu Sheikh Mujib Medical University Journal
Subjects:
Online Access:https://www.asiajol.info/index.php/BSMMUJ/article/view/68731
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author Amina Begum
Md. Shaiful Islam Patwary
Adity Ara Trisha
Shorifa Shahjadi
author_facet Amina Begum
Md. Shaiful Islam Patwary
Adity Ara Trisha
Shorifa Shahjadi
author_sort Amina Begum
collection DOAJ
description Background: Memory impairment is an important presentation of many diseases. Sidestream cigarette smoke (SCS), a form of passive smoke, causes neural complications such as impaired memory. The aim of this study was to assess the effect of sidestream cigarette smoke on memory of male Long-Evans rats. Methods: This experimental study was conducted in the Physiology Department of Bangabandhu Sheikh Mujib Medical University. Twelve male Long-Evans rats, having 150 to 200 grams body weight were collected from central animal house of this University. Rats were divided into fresh air group (control) and experimental group (exposer to SCS for 30 minutes twice daily) for 30 consecutive days. For memory evaluation, Morris water maze (MWM) test was performed. Working memory was measured as escape latency in training and four trial phases. Reference memory (escape latency in acquisition phase and target crossings in probe trial. For estimation of hippocampal antioxidant enzymes, catalase and glutathione peroxidase levels were measured by ELISA. Data were expressed as mean (standard error of mean) and t test was done to compare the two groups. P <0.05 was considered as statistically significant. Results: Two to five times higher escape latency (working memory) was observed in experimental rats compared to those of control rats (P<0.001). Moreover, significantly lower (3.8 versus 7.8) target crossings (P<0.001) were found in experimental rats compared to the control rats. In addition, hippocampal catalase (6.2 versus 17.6 U/mg protein) and glutathione peroxidase (1.9 versus 5.6 U/mg protein) levels were found significantly lower (P<0.001) in experimental rats when compared to control rats. Conclusion: The sidestream cigarette smoke caused memory impairment and decrement of hippocampal antioxidant enzymes level in male Long-Evans rats.
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spelling doaj.art-0bbf5b54bf694e4ea221383230548b562024-04-14T11:44:12ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502024-03-0117110.3329/bsmmuj.v17i1.68731Effect of sidestream cigarette smoking on memory of male Long-Evans ratsAmina Begum0Md. Shaiful Islam Patwary1Adity Ara Trisha2Shorifa Shahjadi3Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Physiology, Central Medical College and Hospital, Cumilla, BangladeshDepartment of Physiology, Dhaka medical college, Dhaka, BangladeshDepartment of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Background: Memory impairment is an important presentation of many diseases. Sidestream cigarette smoke (SCS), a form of passive smoke, causes neural complications such as impaired memory. The aim of this study was to assess the effect of sidestream cigarette smoke on memory of male Long-Evans rats. Methods: This experimental study was conducted in the Physiology Department of Bangabandhu Sheikh Mujib Medical University. Twelve male Long-Evans rats, having 150 to 200 grams body weight were collected from central animal house of this University. Rats were divided into fresh air group (control) and experimental group (exposer to SCS for 30 minutes twice daily) for 30 consecutive days. For memory evaluation, Morris water maze (MWM) test was performed. Working memory was measured as escape latency in training and four trial phases. Reference memory (escape latency in acquisition phase and target crossings in probe trial. For estimation of hippocampal antioxidant enzymes, catalase and glutathione peroxidase levels were measured by ELISA. Data were expressed as mean (standard error of mean) and t test was done to compare the two groups. P <0.05 was considered as statistically significant. Results: Two to five times higher escape latency (working memory) was observed in experimental rats compared to those of control rats (P<0.001). Moreover, significantly lower (3.8 versus 7.8) target crossings (P<0.001) were found in experimental rats compared to the control rats. In addition, hippocampal catalase (6.2 versus 17.6 U/mg protein) and glutathione peroxidase (1.9 versus 5.6 U/mg protein) levels were found significantly lower (P<0.001) in experimental rats when compared to control rats. Conclusion: The sidestream cigarette smoke caused memory impairment and decrement of hippocampal antioxidant enzymes level in male Long-Evans rats. https://www.asiajol.info/index.php/BSMMUJ/article/view/68731memory impairmentsidestrem cigarette smokemorris water mazeantioxidant enzymes
spellingShingle Amina Begum
Md. Shaiful Islam Patwary
Adity Ara Trisha
Shorifa Shahjadi
Effect of sidestream cigarette smoking on memory of male Long-Evans rats
Bangabandhu Sheikh Mujib Medical University Journal
memory impairment
sidestrem cigarette smoke
morris water maze
antioxidant enzymes
title Effect of sidestream cigarette smoking on memory of male Long-Evans rats
title_full Effect of sidestream cigarette smoking on memory of male Long-Evans rats
title_fullStr Effect of sidestream cigarette smoking on memory of male Long-Evans rats
title_full_unstemmed Effect of sidestream cigarette smoking on memory of male Long-Evans rats
title_short Effect of sidestream cigarette smoking on memory of male Long-Evans rats
title_sort effect of sidestream cigarette smoking on memory of male long evans rats
topic memory impairment
sidestrem cigarette smoke
morris water maze
antioxidant enzymes
url https://www.asiajol.info/index.php/BSMMUJ/article/view/68731
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